The chemokine receptor CCR5 Δ32 allele in natalizumab‐treated multiple sclerosis. (14th May 2013)

• Record Type: Journal Article
• Authors: Møller, M.; Søndergaard, H. B.; Koch‐Henriksen, N.; Sorensen, P. S.; Sellebjerg, F.; Oturai, A. B.
• Is Part Of: Acta neurologica Scandinavica. Volume 129:Number 1(2014:Jan.)
• Page Start: 27
• Page End: 31
• Publication Date: 2013-05-14
• Subjects: Neurology -- Periodicals; 616.8
• DOI: 10.1111/ane.12145
• Languages: English
• ISSNs: 0001-6314

Abstract

<abstract abstract-type="main" id="ane12145-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="ane12145-sec-0001" sec-type="section"> <title>Objective</title> <p>The chemokine receptor CCR5 may be important for the recruitment of pathogenic T cells to the CNS in multiple sclerosis (MS). We hypothesized that this chemokine receptor might still be important for T‐cell migration during treatment with anti‐very late antigen (VLA)‐4 antibody. We therefore analysed whether natalizumab‐treated MS patients carrying the <italic>CCR5 Δ32</italic> deletion allele, which results in reduced expression of CCR5 on the cell surface, had lower disease activity.</p> </sec> <sec id="ane12145-sec-0002" sec-type="section"> <title>Methods</title> <p> <italic>CCR5 Δ32</italic> was analysed in 212 natalizumab‐treated MS patients.</p> </sec> <sec id="ane12145-sec-0003" sec-type="section"> <title>Results</title> <p> <italic>CCR5 Δ32</italic> status had no significant impact on the frequency of relapses 1 year prior to natalizumab treatment or during the first 48 weeks of treatment. The multiple sclerosis severity score (MSSS) was significantly lower at baseline in patients carrying <italic>CCR5 Δ32</italic> (<italic>P</italic> = 0.031).</p> </sec> <sec id="ane12145-sec-0004" sec-type="section"> <title>Conclusions</title> <p> <italic>CCR5 Δ32</italic> is not associated with lower disease activity in MS patients treated with natalizumab. We found lower MSSS scores in patients carrying <italic>CCR5 Δ32</italic> compared with the remaining patients, which is consistent with previous studies reporting an association with a more favourable disease course. Further studies are, however, needed before the relationship between <italic>CCR5 Δ32</italic> and disease activity in MS can be definitely established.</p> </sec> </abstract>