Spatiotemporal patterns of the Huntingtin‐interacting protein 1‐related gene in the mouse head. (December 2013)

• Record Type: Journal Article
• Authors: Masuda, Tomoyuki; Sakuma, Chie; Ueno, Takayuki; Yamada, Yuriko; Ohmomo, Hideki; Ueda, Shuichi; Yamagishi, Toshiyuki; Yaginuma, Hiroyuki
• Is Part Of: Congenital anomalies. Volume 53:Number 4(2013:Dec.)
• Page Start: 141
• Page End: 148
• Publication Date: 2013-12
• Subjects: Abnormalities, Human -- Periodicals; 616.043
• DOI: 10.1111/cga.12023
• Languages: English
• ISSNs: 0914-3505

Abstract

<abstract abstract-type="main"> <title>Abstract</title> <p> <italic>Huntingtin‐interacting protein 1‐related</italic> (<italic>Hip1r</italic>) was originally identified due to its homology to <italic>Huntingtin‐interacting protein 1</italic>, which contributes to the development of Huntington's disease (HD). We studied the expression of the mouse <italic>Hip1r</italic> (<italic>mHip1r</italic>) gene in the mouse head by <italic>in situ</italic> hybridization. In early embryogenesis at embryonic day (E) 13, <italic>mHip1r</italic> expression was especially prominent in the olfactory epithelium, cerebral cortex layer 1, cortical plate, and dentate gyrus. During later development from E15 to E17, strong expression of <italic>mHip1r</italic> transcripts continued to be observed in the olfactory epithelium, cortical plate, and dentate gyrus. Furthermore, not only the subplate and subventricular zone of the cortex, but also secretory glands, such as the nasal gland and the submandibular gland, were <italic>mHip1r</italic>‐positive. Other positive tissues included the retinal ganglion cells, vomeronasal organ, trigeminal ganglion, and the developing molar tooth. In the adult mouse brain, similar expression patterns were observed in the cerebral cortex layers and other brain regions except the cerebellum. Additionally, by using an antibody against mHip1r, we confirmed these expression patterns at the protein level. Specific expression of mHip1r in the embryonic brain and secretory glands suggests a possible role for Hip1r in normal development and in the pathology of HD.</p> </abstract>