18FDG PET and PET‐CT for the detection of bone metastases in patients with head and neck cancer. A meta‐analysis. Issue 6 (24th June 2013)

• Record Type: Journal Article
• Authors: Yi, Xuelian; Fan, Min; Liu, Yilin; Zhang, Hongting; Liu, Shixi
• Is Part Of: Journal of medical imaging and radiation oncology. Volume 57:Issue 6(2013:Dec.)
• Page Start: 674
• Page End: 679
• Publication Date: 2013-06-24
• Subjects: Radiology, Medical -- Periodicals; Radiology, Medical -- Australasia -- Periodicals; 616.0757
• DOI: 10.1111/1754-9485.12077
• Languages: English
• ISSNs: 1754-9477

Abstract

<abstract abstract-type="main"> <title>Abstract</title> <sec id="jmiro12077-sec-0001" sec-type="section"> <title>Introduction</title> <p>We performed a meta‐analysis to evaluate ¹⁸FDG PET/PET‐CT for the detection of bone metastases in patients with head and neck cancer.</p> </sec> <sec id="jmiro12077-sec-0002" sec-type="section"> <title>Methods</title> <p>We calculated sensitivities, specificities, likelihood ratios, and constructed summary receiver operating characteristic curves for PET and PET‐CT, respectively. We also compared the performance of PET/PET‐CT with that of bone scintigraphy by analysing studies that had also used bone scintigraphy on the same patients.</p> </sec> <sec id="jmiro12077-sec-0003" sec-type="section"> <title>Results</title> <p>Across 9 PET studies (1621 patients) and 10 PET‐CT studies (1291 patients), sensitivity and specificity of PET were 0.81 and 0.99, and of PET‐CT were 0.89 and 0.99, respectively. In 5 comparative studies (1184 patients), sensitivity and specificity of PET/PET‐CT were 0.85 and 0.98, and of bone scintigraphy were 0.55 and 0.98, respectively.</p> </sec> <sec id="jmiro12077-sec-0004" sec-type="section"> <title>Conclusions</title> <p> ¹⁸FDG PET and PET‐CT have high sensitivity and accuracy for the detection of bone metastasis in patients with head and neck cancer.</p> </sec> </abstract>