Fabrication and characterisation of gelatin-hyaluronic acid/nanobioactive glass hybrid scaffolds for tissue engineering. (1st November 2013)

• Record Type: Journal Article
• Authors: Zhou, Z H; Cao, D F; Huang, T L; Liu, L L; Liu, Q Q; Zhao, Y M; Ou, B L; Zeng, W N; Xu, G R; Tang, A P; Yang, Z M
• Is Part Of: Materials research innovations. Volume 17:Number 7(2013)
• Page Start: 532
• Page End: 536
• Publication Date: 2013-11-01
• Subjects: Materials -- Research -- Periodicals; Matériaux -- Recherche -- Périodiques; 620.1105
• DOI: 10.1179/1433075X13Y.0000000095
• Languages: English
• ISSNs: 1432-8917

Abstract

<abstract> <title> <x xml:space="preserve">Abstract</x> </title> <p>Nanobioactive glass (NBG) particles were synthesised via sol-gel method and characterised by transmission electron microscopy (TEM) and X-ray diffraction (XRD). The new composite biomaterial based on gelatin (Gel) conjugated with hyaluronic acid (HA) and NBG in the ternary SiO₂-CaO-P₂O₅ system was prepared through freeze drying method. The composite scaffold was characterised by using Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM) and thermal analyses. Mechanical properties and swelling behaviour of this composite are compared with properties of Gel-HA/NBG composite of similar material without NBG. The TEM results indicated that the prepared NBG particle size was ∼100 nm. The SEM studies showed that the NBG were homogenously distributed within the Gel/HA matrix and the composite scaffolds showed interconnected pores with a size varied from 50 to 200 μm. The Gel-HA/NBG composite scaffold showed higher compressive strength and better stability than the Gel/HA scaffold. These results indicate that composite scaffolds developed using NBG disseminated Gel/HA matrix as potential scaffolds for tissue engineering applications.</p> </abstract>