GSTM1-null Genotype as a Risk Factor for Sporadic Colorectal Cancer in a Romanian Population. Association with the NAT2-rapid-acetylator Phenotype and Exposure to Environmental Factors. (1st February 2014)

• Record Type: Journal Article
• Authors: Procopciuc, Lucia Maria; Osian, Gelu
• Is Part Of: Cancer investigation. Volume 32:Number 2(2014)
• Page Start: 53
• Page End: 62
• Publication Date: 2014-02-01
• Subjects: Cancer -- Periodicals; Oncology -- Periodicals; Medical Oncology -- Periodicals; Neoplasms -- Periodicals; 616.994
• DOI: 10.3109/07357907.2013.867972
• Languages: English
• ISSNs: 0735-7907

Abstract

<abstract> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>We evaluated the association between the presence of the <italic>GSTM1-null</italic> genotype and the combined presence of the <italic>GSTM1-null</italic> genotype/<italic>NAT2 rapid acetylator</italic> phenotype and the risk of developing sporadic colorectal cancer (CRC), as well as their interaction with environmental risk factors. One hundred and fifty patients with sporadic CRC and 162 controls were genotyped using PCR-RFLP analysis. For testing and quantification of the simple effect (main effect) and of the gene–gene and gene–environment interaction (modification effect), univariate and multivariate logistic regression was used. In the multiplicative model, from the genetic factors, <italic>GSTM1-null</italic> and <italic>NAT2*6B</italic> had a statistically significant influence on the risk for CRC, while from the environmental factors, smoking and diet had similar effects. The combination of <italic>GSTM1-null</italic>/<italic>NAT2 rapid acetylator</italic> phenotype/smoking behavior or <italic>GSTM1-null</italic>/<italic>NAT2 rapid acetylator</italic> phenotype/diet rich in fried red meat was not found to influence the sporadic CRC risk in Romanians, but the <italic>GSTM1-null</italic> genotype, <italic>NAT2 rapid acetylator</italic> phenotype influenced the sporadic CRC risk differently depending on the gender of the patient.</bold> </p> </abstract>