Association of oestrogen-containing contraceptives with pulmonary lymphangioleiomyomatosis in women with tuberous sclerosis complex – Findings from a survey. (February 2014)

• Record Type: Journal Article
• Authors: Sauter, Matthias; Sigl, Jannina; Schotten, Klaus-Jürgen; Günthner-Biller, Margit; Knabl, Julia; Fischereder, Michael
• Is Part Of: European journal of contraception & reproductive health care. Volume 19:Number 1(2014:Feb.)
• Page Start: 39
• Page End: 44
• Publication Date: 2014-02
• Subjects: Contraception -- Periodicals; Reproductive health -- Periodicals; Generative organs, Female -- Periodicals; Contraception -- Periodicals; Reproductive Medicine -- Periodicals; 613.9
• DOI: 10.3109/13625187.2013.859667
• Languages: English
• ISSNs: 1362-5187

Abstract

<abstract> <title>Abstract</title> <p> <bold>Objectives</bold> About 30–40% of women with tuberous sclerosis complex (TSC) develop pulmonary lymphangioleiomyomatosis (LAM). Oestrogen seems to be involved in LAM pathogenesis and oestrogen-containing contraception should be avoided in women with known LAM. However, there is very little data on the use of contraceptives in TSC patients.</p> <p> <bold>Methods</bold> We conducted a survey on the use of contraception and disease characteristics. The questionnaire was forwarded to all adult female TSC patients listed in the database of a German patient organisation.</p> <p> <bold>Results</bold> Data from 39 such patients could be analysed. Of these, 15 were diagnosed with LAM. Twenty-five patients (65%) confirmed current or past use of oestrogen- containing contraceptives. We found a suggestive correlation between the history of oestrogen-containing contraception, and LAM (Odds ratio: 6.500; 95% confidence interval: 1.199–35.230). However, oestrogen use was not associated with LAM complications.</p> <p> <bold>Conclusions</bold> Based on our findings, oestrogen-containing contraceptives should be resorted to by these patients only with great caution, and avoided whenever possible.</p> </abstract>