Rate of control of LDL cholesterol and incident hypertension requiring antihypertensive treatment in hypercholesterolemic subjects in daily clinical practice. (March 2014)

• Record Type: Journal Article
• Authors: Borghi, Claudio; Cicero, Arrigo F. G.; Saragoni, Stefania; Buda, Stefano; Cristofori, Cristina; Lilli, Paolo; Degli Esposti, Luca
• Is Part Of: Annals of medicine. Volume 46:Number 2(2014)
• Page Start: 97
• Page End: 102
• Publication Date: 2014-03
• Subjects: Medicine -- Periodicals; 610
• DOI: 10.3109/07853890.2013.870019
• Languages: English
• ISSNs: 0785-3890

Abstract

<abstract> <title>Abstract</title> <p> <italic>Introduction.</italic> Preliminary evidence suggests that hypercholesterolemia is associated to an increased risk to develop hypertension. We aimed at evaluating the association between low-density lipoprotein cholesterol (LDL-C) level and incidence of new onset of hypertension in a large population sample.</p> <p> <italic>Materials and methods.</italic> A population-based cohort of 20, 074 subjects with at least one LDL-C measurement between July 2006 and June 2007 and free of antihypertensive treatment (AHT) at baseline was followed from the LDL-C date until death or 31 December 2009.</p> <p> <italic>Results.</italic> During the follow-up, 10.7% of patients with LDL-C < 130 mg/dL, 13.2% of patients with LDL-C between 130 and 159 mg/dL, 12.2% of patients with LDL-C between 160 and 189 mg/dL, and 13.9% of patients with LDL-C ≥ 190 mg/dL had new-onset hypertension requiring the initiation of AHT. Compared with the LDL-C < 130 mg/dL group, the hazard ratio (HR) of initiation of AHT increased among those with LDL-C level between 130 and 159 mg/dL (HR 1.23; 95% CI: 1.08–1.40), those with LDL-C level between 160 and 189 mg/dL (HR 1.24; 95% CI: 1.01–1.51), and those with LDL-C ≥ 190 mg/dL (HR 1.45; 95% CI: 1.11–1.89).</p> <p> <italic>Conclusion.</italic> A better control of cholesterolemia seems to be associated to a lower incidence of new-onset of hypertension requiring AHT in a large cohort of general population.</p> </abstract>