Signaling pathways controlling skeletal muscle mass. (January 2014)

• Record Type: Journal Article
• Authors: Egerman, Marc A.; Glass, David J.
• Is Part Of: Critical reviews in biochemistry and molecular biology. Volume 49:Number 1(2014:Jan./Feb.)
• Page Start: 59
• Page End: 68
• Publication Date: 2014-01
• Subjects: Biochemistry -- Periodicals; Molecular biology -- Periodicals; Biochemistry -- Periodicals; Molecular Biology -- Periodicals; Review Literature -- Periodicals; 572
• DOI: 10.3109/10409238.2013.857291
• Languages: English
• ISSNs: 1040-9238

Abstract

<abstract> <title>Abstract</title> <p>The molecular mechanisms underlying skeletal muscle maintenance involve interplay between multiple signaling pathways. Under normal physiological conditions, a network of interconnected signals serves to control and coordinate hypertrophic and atrophic messages, culminating in a delicate balance between muscle protein synthesis and proteolysis. Loss of skeletal muscle mass, termed "atrophy", is a diagnostic feature of cachexia seen in settings of cancer, heart disease, chronic obstructive pulmonary disease, kidney disease, and burns. Cachexia increases the likelihood of death from these already serious diseases. Recent studies have further defined the pathways leading to gain and loss of skeletal muscle as well as the signaling events that induce differentiation and post-injury regeneration, which are also essential for the maintenance of skeletal muscle mass. In this review, we summarize and discuss the relevant recent literature demonstrating these previously undiscovered mediators governing anabolism and catabolism of skeletal muscle.</p> </abstract>