Relation of antimullerian hormone with the clinical signs of hyperandrogenism and polycystic ovary morphology. (February 2014)

• Record Type: Journal Article
• Authors: Sahmay, Sezai; Aydın, Yavuz; Atakul, Nil; Aydogan, Begum; Kaleli, Semih
• Is Part Of: Gynecological endocrinology. Volume 30:Number 2(2014:Feb.)
• Page Start: 130
• Page End: 134
• Publication Date: 2014-02
• Subjects: Endocrine gynecology -- Periodicals; Generative organs, Female -- Diseases -- Periodicals; 618.1
• DOI: 10.3109/09513590.2013.867320
• Languages: English
• ISSNs: 0951-3590

Abstract

<abstract> <title>Abstract</title> <p>The relation of antimullerian hormone (AMH) levels with the clinical and biochemical markers of polycystic ovary syndrome (PCOS) could be different. A total of 463 PCOS patients were evaluated in this cross-sectional study. Groups were constructed according to polycystic ovarian morphology (PCOM) and menstrual cycle-length. The relation of serum AMH with androgenic hormones, menstrual cycle-length and clinical signs of PCOS were investigated. A powerful positive relation was found between the PCOM and AMH levels (odds ratio = 2.49). There was a negative correlation between age and AMH level (<italic>p</italic> < 0.001, <italic>r</italic>[correlation coefficent] = −0.155). Positive correlations were found between luteinizing hormone (LH) and AMH (<italic>p</italic> < 0.001, <italic>r</italic> = 0.25) and also between cycle length and AMH (<italic>p</italic> < 0.01, <italic>r</italic> = 0.27). We found a negative week correlation between AMH and follicle-stimulating hormone (FSH) (<italic>p</italic> = 0.01, <italic>r</italic> = −0.19). After controlling main androgenic hormones, AMH was found to be correlated with the Ferriman–Gallway score (<italic>p</italic> = 0.03, <italic>r</italic> = 0.18). There was a positive relationship between hirsutism and AMH (odds ratio = 1.43), but no correlation between AMH and other parameters of clinical hyperandrogenism like hair-loss, acne and seborrhea were identified. The strongest relation was presented between the AMH levels and PCOM. Also, cycle-length correlated well with the AMH levels. The relationship between hirsutism and AMH is found to be independent from androgenic hormones.</p> </abstract>