Recurrent spontaneous abortions, Hashimoto thyroiditis and alopecia totalis: response to anticoagulation and intravenous immunoglobulin therapy. (February 2014)

• Record Type: Journal Article
• Authors: Bozic Antic, Ivana; Macut, Djuro; Popovic, Bojana; Isailovic, Tatjana; Petakov, Milan; Ognjanovic, Sanja; Damjanovic, Svetozar
• Is Part Of: Gynecological endocrinology. Volume 30:Number 2(2014:Feb.)
• Page Start: 100
• Page End: 102
• Publication Date: 2014-02
• Subjects: Endocrine gynecology -- Periodicals; Generative organs, Female -- Diseases -- Periodicals; 618.1
• DOI: 10.3109/09513590.2013.864271
• Languages: English
• ISSNs: 0951-3590

Abstract

<abstract> <title>Abstract</title> <p> <italic>Introduction</italic>: Although numerous studies indicated a link between antithyroid antibodies and recurrent spontaneous abortions (RSA), consensus on the treatment of this condition is still lacking.</p> <p> <italic>Case report</italic>: We present a case of a 35-year-old pregnant woman (gestation week 4) with primary hypothyroidism, total alopecia, high level of positive antithyroid antibodies, and history of two recurrent spontaneous abortions in early pregnancy. Along with L-thyroxin substitution, intravenous human immunoglobulin (IVIg) combined with anticoagulation and antiaggregation therapy was introduced. During pregnancy her scalp hair completely re-grew, and following gestation week 39 she delivered healthy female child.</p> <p> <italic>Conclusion</italic>: Thyroid antibodies could contribute to previous recurrent abortions in our patient. It is suggested that in older primiparas with Hashimoto thyroiditis and history of RSA, a combined treatment with IVIg, anticoagulation and antiaggregation therapy should be considered.</p> </abstract>