Morphologic Characteristics of Blastic Plasmacytoid Dendritic Cell Neoplasm: A Case Report. (February 2014)

• Record Type: Journal Article
• Authors: Ru, Yongxin; Zhang, Peihong; Dong, Shuxu; Wang, Huijun; Zhao, Shixuan; Mi, Yingchang; Eyden, Brian
• Is Part Of: Ultrastructural pathology. Volume 38:Number 1(2014:Feb.)
• Page Start: 66
• Page End: 68
• Publication Date: 2014-02
• Subjects: Pathology, Cellular -- Periodicals; Ultrastructure (Biology) -- Periodicals; Diagnosis, Electron microscopic -- Periodicals; Microscopy, Electron; Pathology; 616.07582
• DOI: 10.3109/01913123.2013.813998
• Languages: English
• ISSNs: 0191-3123

Abstract

<abstract> <title>Abstract</title> <p>Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare aggressive lymphoma derived from plasmacytoid dendritic cells or precursor dendritic cells. Despite some 240 reported cases, its morphology and especially ultrastructure has not been satisfactorily studied. A case is reported of a 13 year old boy, who, despite chemotherapy, died within a 12-month period. The electron microscopy findings – microvillous processes, nuclei with slight irregularities, a moderate amount of heterochromatin, and rough endoplasmic reticulum in the form of long, narrow profiles, often in parallel arrangements – taken together, serve to distinguish BPDCN from other neoplastic cells, such as monocytes, plasma cells and the cells of chronic lymphocyte leukemia.</p> </abstract>