Efficacy of micafungin in invasive candidiasis caused by common Candida species with special emphasis on non‐albicans Candida species. Issue 2 (20th June 2013)

• Record Type: Journal Article
• Authors: Cornely, Oliver A.; Vazquez, Jose; De, Jan; Betts, Robert; Rotstein, Coleman; Nucci, Marcio; Pappas, Peter G.; Ullmann, Andrew J.
• Is Part Of: Mycoses. Volume 57:Issue 2(2014)
• Page Start: 79
• Page End: 89
• Publication Date: 2013-06-20
• Subjects: Pathogenic fungi -- Periodicals; Medical mycology -- Periodicals; 616.969
• DOI: 10.1111/myc.12104
• Languages: English
• ISSNs: 0933-7407

Abstract

<abstract abstract-type="main" id="myc12104-abs-0001"> <title>Summary</title> <p>The incidence of invasive candidiasis caused by non‐<italic>albicans Candida</italic> (NAC) spp. is increasing. The aim of this analysis was to evaluate the efficacy of micafungin, caspofungin and liposomal amphotericin B in patients with invasive candidiasis and candidaemia caused by different <italic>Candida</italic> spp. This <italic>post hoc</italic> analysis used data obtained from two randomised phase III trials was conducted to evaluate the efficacy and safety of micafungin vs. caspofungin and micafungin vs. liposomal amphotericin B. Treatment success, clinical response, mycological response and mortality were evaluated in patients infected with <italic>C. albicans</italic> and NAC spp. Treatment success rates in patients with either <italic>C. albicans</italic> or NAC infections were similar. Outcomes were similar for micafungin, caspofungin and liposomal amphotericin B. <italic>Candida albicans</italic> was the most prevalent pathogen recovered (41.0%), followed by <italic>C. tropicalis</italic> (17.9%)<italic>, C. parapsilosis</italic> (14.4%), <italic>C. glabrata</italic> (10.4%), multiple <italic>Candida</italic> spp. (7.3%) and <italic>C. krusei</italic> (3.2%). Age, primary diagnosis (i.e. candidaemia or invasive candidiasis), previous corticosteroid therapy and Acute Physiology and Chronic Health Evaluation II score were identified as potential predictors of treatment success and mortality. Micafungin, caspofungin and liposomal amphotericin B exhibit favourable treatment response rates that are comparable for patients infected with different <italic>Candida</italic> spp.</p> </abstract>