Epstein–Barr virus‐associated T/natural killer‐cell lymphomas in the elderly: The first consensus meeting in Kofu 2013. Issue 1 (January 2014)

• Record Type: Journal Article
• Authors: Hamada, Toshihisa; Nakamura, Shigeo; Ko, Young‐Hyeh; Yoshino, Tadashi; Ohshima, Koichi; Matsuzawa, Takamitsu; Miura, Keiko; Takahashi, Toshifumi; Nomura, Hisashi; Hoshino, Tomomi; Suzuki, Daisuke; Shimada, Shinji; Iwatsuki, Keiji
• Is Part Of: Journal of dermatology. Volume 41:Issue 1(2014)
• Page Start: 40
• Page End: 42
• Publication Date: 2014-01
• Subjects: Dermatology -- Periodicals; Dermatology -- Japan -- Periodicals; Skin -- Diseases -- Periodicals; 616.5005
• DOI: 10.1111/1346-8138.12373
• Languages: English
• ISSNs: 0385-2407

Abstract

<abstract abstract-type="main" id="jde12373-abs-0001"> <title>Abstract</title> <p>From a clinicopathological conference on nine elderly patients with Epstein–Barr virus (EBV)‐associated T/natural killer (NK)‐cell lymphoma, we have addressed the patients' backgrounds, clinical manifestations, histopathological findings, cytogenesis, complications and prognoses. Among these elderly patients (&gt;65 years old), seven patients had extranodal NK/T‐cell lymphoma, nasal type (ENKL) with an NK‐cell phenotype, and two patients had EBV⁺ T‐cell lymphomas or lymphoproliferative disorders (LPD) with cutaneous lesions mimicking pityriasis lichenoides et varioliformis acuta (PLEVA) or hydroa vacciniforme (HV). No patients had a previous episode of EBV‐related symptoms such as infectious mononucleosis, chronic active EBV infection, HV or hypersensitivity to mosquito bites. Elderly patients with ENKL may show the centroblastoid variant. EBV⁺CD8⁺CD56^+/− lymphocytes may be responsible for the development of PLEVA or HV‐like cutaneous lesions in the elderly.</p> </abstract>