Environmental fungicides and triazole resistance in Aspergillus. Issue 2 (5th December 2013)

• Record Type: Journal Article
• Authors: Bowyer, Paul; Denning, David W
• Is Part Of: Pest management science. Volume 70:Issue 2(2014:Feb.)
• Page Start: 173
• Page End: 178
• Publication Date: 2013-12-05
• Subjects: Pests -- Control -- Periodicals; Pesticides -- Periodicals; 632.9
• DOI: 10.1002/ps.3567
• Languages: English
• ISSNs: 1526-498X

Abstract

<abstract abstract-type="main" id="ps3567-abs-0001"> <title>Abstract</title> <p id="ps3567-para-0001"> <bold>Fungal diseases are problematic in both human health and agriculture. Treatment options are limited and resistance may emerge. The relatively recent recognition of triazole resistance in <italic>Aspergillus fumigatus</italic> has prompted questioning of the origin of resistance. While multiple mechanisms are described in clinical isolates from triazole‐treated patients, some <italic>de novo</italic> resistance is also recognised, especially attributable to TR₃₄/L98H. Such strains probably arose in the environment, and, indeed, multiple studies have now demonstrated TR₃₄/L98H triazole resistance strains of <italic>A. fumigatus</italic> from soil. Docking and other <italic>in vitro</italic> studies are consistent with environmental resistance induction through exposure to certain triazole fungicides, notably difenoconazole, propiconazole, epoxiconazole, bromuconazole and tebuconazole. This article addresses the potential implications of this issue for both human health and food security. © 2013 Society of Chemical Industry</bold> </p> </abstract>