Evaluation of mucoadhesive carrier adjuvant: Toward an oral anthrax vaccine. (February 2014)

• Record Type: Journal Article
• Authors: Mangal, Sharad; Pawar, Dilip; Agrawal, Udita; Jain, Arvind K.; Vyas, Suresh P.
• Is Part Of: Artificial cells, nanomedicine, and biotechnology. Volume 42:Number 1(2014:Feb.)
• Page Start: 47
• Page End: 57
• Publication Date: 2014-02
• Subjects: Artificial cells -- Periodicals; Nanotechnology -- Periodicals; Blood substitutes -- Periodicals; Tissue engineering -- Periodicals; Molecules -- Periodicals; Biotechnology -- Periodicals; 615.39
• DOI: 10.3109/21691401.2013.769447
• Languages: English
• ISSNs: 2169-1401

Abstract

<abstract> <title>Abstract</title> <p>The aim of present study was to evaluate the potential of mucoadhesive alginate-coated chitosan microparticles (A-CHMp) for oral vaccine against anthrax. The zeta potential of A-CHMp was − 29.7 mV, and alginate coating could prevent the burst release of antigen in simulated gastric fluid. The results indicated that A-CHMp was mucoadhesive in nature and transported it to the peyer's patch upon oral delivery. The immunization studies indicated that A-CHMp resulted in the induction of potent systemic and mucosal immune responses, whereas alum-adjuvanted rPA could induce only systemic immune response. Thus, A-CHMp represents a promising acid carrier adjuvant for oral immunization against anthrax.</p> </abstract>