Relation of Vitamin D Status to Congestive Heart Failure and Cardiovascular Events in Dogs. (7th November 2013)

• Record Type: Journal Article
• Authors: Kraus, M.S.; Rassnick, K.M.; Wakshlag, J.J.; Gelzer, A.R.M.; Waxman, A.S.; Struble, A.M.; Refsal, K.
• Is Part Of: Journal of veterinary internal medicine. Volume 28:Number 1(2014:Jan./Feb.)
• Page Start: 109
• Page End: 115
• Publication Date: 2013-11-07
• Subjects: Veterinary medicine -- Periodicals; 636.0896
• DOI: 10.1111/jvim.12239
• Languages: English
• ISSNs: 0891-6640

Abstract

<abstract abstract-type="main" id="jvim12239-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="jvim12239-sec-0001" sec-type="section"> <title>Background</title> <p>Vitamin D plays a pivotal role in cardiac function, and there is increasing evidence that vitamin D deficiency is associated with the development of congestive heart failure (CHF) in people.</p> </sec> <sec id="jvim12239-sec-0002" sec-type="section"> <title>Hypothesis</title> <p>Serum vitamin D concentration is lower in dogs with CHF compared with unaffected controls and serum vitamin D concentration is associated with clinical outcome in dogs with CHF.</p> </sec> <sec id="jvim12239-sec-0003" sec-type="section"> <title>Animals</title> <p>Eighty‐two client‐owned dogs.</p> </sec> <sec id="jvim12239-sec-0004" sec-type="section"> <title>Methods</title> <p>In this cross‐sectional study, we examined the association between circulating 25‐hydroxyvitamin D [25(OH)D], a measure of vitamin D status, and CHF in dogs. In the prospective cohort study, we examined whether 25(OH)D serum concentration was associated with clinical outcome in dogs with CHF.</p> </sec> <sec id="jvim12239-sec-0005" sec-type="section"> <title>Results</title> <p>Mean 25(OH)D concentration (100 ± 44 nmol/L) in 31 dogs with CHF was significantly lower than that of 51 unaffected dogs (123 ± 42 nmol/L; <italic>P</italic> = .023). The mean calculated vitamin D intake per kg of metabolic body weight in dogs with CHF was no different from that of unaffected dogs (1.37 ± 0.90 μg/kg metabolic body weight versus 0.98 ± 0.59 μg/kg body weight, respectively, <italic>P</italic> = .097). There was a significant association of serum 25(OH)D concentration on time to clinical manifestation of CHF or sudden death (<italic>P</italic> = .02).</p> </sec> <sec id="jvim12239-sec-0006" sec-type="section"> <title>Conclusion and Clinical Relevance</title> <p>These findings suggest that low concentrations of 25(OH)D may be a risk factor for CHF in dogs. Low serum 25(OH)D concentration was associated with poor outcome in dogs with CHF. Strategies to improve vitamin D status in some dogs with CHF may prove beneficial without causing toxicity.</p> </sec> </abstract>