IL28RA polymorphism (rs10903035) is associated with insulin resistance in HIV/HCV‐coinfected patients. Issue 3 (17th July 2013)

• Record Type: Journal Article
• Authors: Jiménez‐Sousa, M. A.; Berenguer, J.; Fernández‐Rodríguez, A.; Micheloud, D.; Guzmán‐Fulgencio, M.; Miralles, P.; Pineda‐Tenor, D.; García–Álvarez, M.; López, J. C.; Aldámiz‐Echevarria, T.; Carrero, A.; Resino, S.
• Is Part Of: Journal of viral hepatitis. Volume 21:Issue 3(2014)
• Page Start: 189
• Page End: 197
• Publication Date: 2013-07-17
• Subjects: Hepatitis, Viral -- Periodicals; Hepatitis, Viral, Animal; Hepatitis, Viral, Human; 616.3623
• DOI: 10.1111/jvh.12130
• Languages: English
• ISSNs: 1352-0504

Abstract

<abstract abstract-type="main" id="jvh12130-abs-0001"> <title>Summary</title> <p>Hepatitis C virus (HCV) infection is associated with insulin resistance (IR), although mechanisms leading to IR in these patients are not completely understood. The aim of this study was to evaluate the association of <italic>interleukin 28B</italic> (<italic>IL28B)</italic> and interleukin 28 receptor alpha (<italic>IL28RA</italic>) polymorphisms with IR among human immunodeficiency virus (HIV)/HCV‐coinfected patients. We carried out a cross‐sectional study on 203 patients. <italic>IL28B</italic> (rs8099917) and <italic>IL28RA (</italic>rs10903035) polymorphisms were genotyped by GoldenGate<sup>®</sup> assay. IR was defined as homeostatic model assessment (HOMA) values ≥3.00. Univariate and multivariate generalized linear models (GLM) were used to compare HOMA values and the percentage of patients with IR according to <italic>IL28B</italic> and <italic>IL28RA</italic> genotypes. In total, 32% (<italic>n</italic> = 65/203) of the patients had IR. <italic>IL28B</italic> rs8099917 TT was not significantly associated with HOMA values and IR. In contrast, rs10903035 AA was significantly associated with high HOMA values taking into account all patients (<italic>P</italic> = 0.024), as well as the subgroups of patients with significant fibrosis (<italic>P</italic> = 0.047) and infected with HCV genotype 3 (<italic>P</italic> = 0.024). Additionally, rs10903035 AA was significantly associated with IR (HOMA ≥3.00) in all patients (adjusted odds ratio (aOR) = 2.02; <italic>P</italic> = 0.034), in patients with significant fibrosis (aOR = 2.86; <italic>P</italic> = 0.039) and HCV genotype 3 patients (aOR = 4.89; <italic>P</italic> = 0.031). In conclusions, <italic>IL28RA</italic> polymorphism (rs10903035) seems to be implicated in the glucose homeostasis because AA genotype increases the likelihood of IR, but this association was different depending on hepatic fibrosis and HCV genotype.</p> </abstract>