Chronic migraine in women is associated with insulin resistance: a cross‐sectional study. (15th November 2013)

• Record Type: Journal Article
• Authors: Fava, A.; Pirritano, D.; Consoli, D.; Plastino, M.; Casalinuovo, F.; Cristofaro, S.; Colica, C.; Ermio, C.; De, M.; Opipari, C.; Lanzo, R.; Consoli, A.; Bosco, D.
• Is Part Of: European journal of neurology. Volume 21:Number 2(2014:Feb.)
• Page Start: 267
• Page End: 272
• Publication Date: 2013-11-15
• Subjects: Neurology -- Periodicals; Nervous system -- Diseases -- Periodicals; 616.8
• DOI: 10.1111/ene.12289
• Languages: English
• ISSNs: 1351-5101

Abstract

<abstract abstract-type="main" id="ene12289-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="ene12289-sec-0001" sec-type="section"> <title>Background and purpose</title> <p>Migraine is a common neurological disorder. It can be divided into episodic migraine (EM) and chronic migraine (CM), based on headache frequency. Some studies have shown that insulin sensitivity is impaired in migraine; moreover, hypertension, diabetes and obesity are common in patients with CM. The aim of this study was to assess serum glucose, insulin levels and insulin resistance (IR) in a sample of episodic migraineurs, chronic migraineurs and non‐pain healthy controls.</p> </sec> <sec id="ene12289-sec-0002" sec-type="section"> <title>Methods</title> <p>Eighty‐three women with EM, 83 with CM and 83 healthy controls were recruited. Headache was diagnosed according to the latest International Classification of Headache Disorders 2 criteria. Waist circumference, body mass index (BMI) and blood pressure were measured. Checked metabolic parameters included fasting glucose, the 2 h 75 g oral glucose tolerance test (2 h OGTT), serum HbA1c, blood lipid profile, C‐reactive protein and prolactin. The homeostasis model assessment formula was used to calculate IR.</p> </sec> <sec id="ene12289-sec-0003" sec-type="section"> <title>Results</title> <p>A significant prevalence of IR in CM was observed (<italic>P</italic> = 0.002). No significant associations were found with fasting glycaemia, the 2 h OGTT, HbA1c, blood lipid profile, C‐reactive protein, prolactin and waist circumference. Obesity (BMI >30 kg/m<sup>2</sup>) was associated with an increased risk of CM [odds ratio (OR) 2.4]. When the outcome of interest was the association between IR and obesity, the OR was significantly increased compared with IR alone (OR = 13.2).</p> </sec> <sec id="ene12289-sec-0004" sec-type="section"> <title>Conclusion</title> <p>This may suggest that CM is associated with IR status, particularly when it is in partnership with obesity.</p> </sec> </abstract>