Dysarthria plus dysphagia is associated with severe sleep‐disordered breathing in patients with acute intracerebral hemorrhage. (7th December 2013)

• Record Type: Journal Article
• Authors: Shibazaki, K.; Kimura, K.; Aoki, J.; Uemura, J.; Fujii, S.; Sakai, K.
• Is Part Of: European journal of neurology. Volume 21:Number 2(2014:Feb.)
• Page Start: 344
• Page End: 348
• Publication Date: 2013-12-07
• Subjects: Neurology -- Periodicals; Nervous system -- Diseases -- Periodicals; 616.8
• DOI: 10.1111/ene.12323
• Languages: English
• ISSNs: 1351-5101

Abstract

<abstract abstract-type="main" id="ene12323-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="ene12323-sec-0001" sec-type="section"> <title>Background and purpose</title> <p>Sleep‐disordered breathing (SDB) is a risk factor for stroke. The frequency of SDB in Japanese patients with acute intracerebral hemorrhage (ICH) was investigated, as well as factors associated with SDB severity.</p> </sec> <sec id="ene12323-sec-0002" sec-type="section"> <title>Methods</title> <p>Between April 2010 and April 2013, patients with ICH within 24 h of onset were prospectively enrolled to participate in a sleep study within 7 days of admission. SDB was defined as a respiratory disturbance index (RDI: apnea or hypopnea events per hour) of ≥5. Patients were assigned to groups based on RDI values of ≥30 (severe SDB) and <30 (absent or not severe SDB). The frequency of SDB and factors associated with its severity were investigated using multivariate logistic regression analysis.</p> </sec> <sec id="ene12323-sec-0003" sec-type="section"> <title>Results</title> <p>Of 97 patients (55 males; mean age 68.1 years) enrolled in the study, 91 (94%) had SDB. Severe SDB was evident in 29 (30%) patients. Compared with the RDI< 30 group, the RDI≥ 30 group had a higher frequency of dysarthria plus dysphagia (76% vs. 47%, <italic>P</italic> = 0.008), larger waist circumference [86 (84–92) vs. 84 (78–88) cm, <italic>P</italic> = 0.019] and a greater body mass index [23.8 (21.1–26.8) vs. 21.5 (19.4–25.0) kg/m<sup>2</sup>, <italic>P</italic> = 0.046]. Multivariate logistic regression analysis showed that dysarthria plus dysphagia was independently associated with severe SDB (odds ratio 3.4; 95% confidence interval 1.250–9.252, <italic>P</italic> = 0.017).</p> </sec> <sec id="ene12323-sec-0004" sec-type="section"> <title>Conclusion</title> <p>Most Japanese patients with acute ICH had SDB, and dysarthria plus dysphagia was associated with severe SDB.</p> </sec> </abstract>