Urinary profile of catecholamines and metabolites in Parkinson patients with deep brain stimulation. (17th May 2013)

• Record Type: Journal Article
• Authors: Guimarães, J.; Vieira‐Coelho, M. A.; Moura, E.; Afonso, J.; Rosas, M. J.; Vaz, R.; Garrett, C.
• Is Part Of: European journal of neurology. Volume 21:Number 2(2014:Feb.)
• Page Start: 353
• Page End: 356
• Publication Date: 2013-05-17
• Subjects: Neurology -- Periodicals; Nervous system -- Diseases -- Periodicals; 616.8
• DOI: 10.1111/ene.12161
• Languages: English
• ISSNs: 1351-5101

Abstract

<abstract abstract-type="main" id="ene12161-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="ene12161-sec-0001" sec-type="section"> <title>Background and purpose</title> <p>Deep brain stimulation of the subthalamic nucleus (DBS‐STN) is thought to continuously alter the activity of STN neurons in Parkinson's disease (PD). A chronic decrease in the levodopa dose with continuous STN stimulation may induce plastic neuronal changes.</p> </sec> <sec id="ene12161-sec-0002" sec-type="section"> <title>Objective</title> <p>The objective of this work was to study urinary excretion of catecholamines in patients with PD before and after DBS‐STN.</p> </sec> <sec id="ene12161-sec-0003" sec-type="section"> <title>Methods</title> <p>Twenty‐three patients were submitted to DBS‐STN, and evaluated before and after surgery with respect to catecholamines and metabolites in 24‐h urine measured by high‐performance liquid chromatography with electrochemical detection.</p> </sec> <sec id="ene12161-sec-0004" sec-type="section"> <title>Results</title> <p>Of the 23 patients evaluated, a significant decrease of about 60% in the urinary excretion of <sc>l</sc>‐3, 4‐dihydroxyphenylalanine (<sc>l</sc>‐DOPA; in nmol/mg creatinine/24 h) was observed 1 week after DBS‐STN. Moreover, in 17 patients with a follow‐up of 8 weeks after surgery, there was a further 50% decrease in urinary <sc>l</sc>‐DOPA levels, dropping to about 75% of the values before surgery. There was also a significant decrease in dopamine (DA) and 3, 4‐dihydroxyphenylacetic acid (DOPAC) levels 1 week after DBS‐STN that was no longer present 8 weeks after. A significant increase in the DA/<sc>l</sc>‐DOPA ratio was observed 1 week after surgery, with a further increase 8 weeks after surgery.</p> </sec> <sec id="ene12161-sec-0005" sec-type="section"> <title>Conclusion</title> <p>After DBS‐STN, the DA/<sc>l</sc>‐DOPA ratio, an indirect measure of DA synthesis, increased. These results show that DBS‐STN may improve the efficacy of oral levodopa.</p> </sec> </abstract>