General practice‐recorded depression and antidepressant use in young people with newly diagnosed Type 1 diabetes: a cohort study using the Clinical Practice Research Datalink. Issue 2 (21st October 2013)

• Record Type: Journal Article
• Authors: Morgan, E.; Patterson, C. C.; Cardwell, C. R.
• Is Part Of: Diabetic medicine. Volume 31:Issue 2(2014:Feb.)
• Page Start: 241
• Page End: 245
• Publication Date: 2013-10-21
• Subjects: Diabetes -- Periodicals; 616.462
• DOI: 10.1111/dme.12330
• Languages: English
• ISSNs: 0742-3071

Abstract

<abstract abstract-type="main" id="dme12330-abs-0001"> <title>Abstract</title> <sec id="dme12330-sec-0001" sec-type="section"> <title>Aims</title> <p>To investigate whether young people with Type 1 diabetes have an increased rate of depression and antidepressant use and whether their risk varies by age group, time from diabetes diagnosis, calendar period of diagnosis or complications status.</p> </sec> <sec id="dme12330-sec-0002" sec-type="section"> <title>Methods</title> <p>A cohort of incident cases of patients with Type 1 diabetes diagnosed before 35 years of age (<italic>n</italic> = 5548) was identified within the Clinical Practice Research Datalink and individually age and sex matched with up to two control subjects without diabetes (<italic>n</italic> = 10 657). Patients with depression were identified through general practice‐recorded depression codes and antidepressant prescriptions. Cox regression models gave hazard ratios for depression in people with Type 1 diabetes compared with control subjects.</p> </sec> <sec id="dme12330-sec-0003" sec-type="section"> <title>Results</title> <p>People with Type 1 diabetes were twice as likely to have a record of antidepressant use and general practice‐diagnosed depression as their matched control subjects (hazard ratio 2.08, 95% CI 1.73–2.50, <italic>P</italic> < 0.001). These associations varied by time from diagnosis, with marked increases observed within the first 5 years of diagnosis (hazard ratio 2.14, 95% CI 1.51–3.03, <italic>P</italic> < 0.001), and by age at diabetes diagnosis, with excesses noted even in the 10‐ to 19‐year age group (hazard ratio 1.45, 95% CI 1.06–1.98, <italic>P</italic> = 0.02).</p> </sec> <sec id="dme12330-sec-0004" sec-type="section"> <title>Conclusions</title> <p>This population‐based study shows that people with Type 1 diabetes have higher rates of general practice‐recorded depression and antidepressant use. The excess is present within 5 years of diabetes diagnosis, suggesting psychological input for patients is warranted in the early years of their condition.</p> </sec> </abstract>