Ethnic differences in the effects of hepatic fat deposition on insulin resistance in nonobese middle school girls. (17th September 2013)

• Record Type: Journal Article
• Authors: Wolfgram, Peter M.; Connor, Ellen L.; Rehm, Jennifer L.; Eickhoff, Jens C.; Reeder, Scott B.; Allen, David B.
• Is Part Of: Obesity. Volume 22:Number 1(2014:Jan.)
• Page Start: 243
• Page End: 248
• Publication Date: 2013-09-17
• Subjects: Obesity -- Periodicals; 616.398005
• DOI: 10.1002/oby.20521
• Languages: English
• ISSNs: 1930-7381

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="oby20521-sec-0001" sec-type="section"> <title>Objective</title> <p>In nonobese youth, to investigate whether hepatic fat deposition and its metabolic consequences vary between ethnic groups.</p> </sec> <sec id="oby20521-sec-0002" sec-type="section"> <title>Design and Methods</title> <p>Thirty‐two nonobese girls (12 Hispanic White [H] and 20 non‐Hispanic White [NHW] girls), aged 11‐14 years old were recruited. Outcome measures were MRI measured hepatic proton density fat fraction (hepatic PDFF), BMI <italic>Z</italic>‐score, waist circumference, fasting insulin, glucose, adiponectin, sex hormone‐binding globulin [SHBG], ALT, AST, triglycerides, and HOMA‐IR.</p> </sec> <sec id="oby20521-sec-0003" sec-type="section"> <title>Results</title> <p>There were no significant differences in mean BMI <italic>Z</italic>‐scores (<italic>P</italic> = 0.546) or hepatic PDFF (<italic>P</italic> = 0.275) between H and NHW girls; however, H girls showed significant correlations between hepatic PDFF and markers of IR (fasting insulin, HOMA‐IR, adiponectin, SHBG, triglycerides; all <italic>P</italic> < 0.05), while NHW girls showed no significant correlations. Matched by hepatic PDFF or BMI <italic>Z</italic>‐score, H girls had more evidence of IR for a given hepatic PDFF (mean insulin, HOMA‐IR, and SHBG; all <italic>P</italic> < 0.05) or BMI <italic>Z</italic>‐score (mean insulin and HOMA‐IR; all <italic>P</italic> < 0.01) than NHW girls.</p> </sec> <sec id="oby20521-sec-0004" sec-type="section"> <title>Conclusions</title> <p>In nonobese female youth, ethnicity‐related differences in effects of hepatic fat on IR are evident, so that in H girls, a given amount of hepatic fat appears to result in a more predictable and greater degree of IR than in NHW girls.</p> </sec> </abstract>