Neuropeptide S receptor gene (NPSR) and life events: G × E effects on anxiety sensitivity and its subdimensions. (January 2014)

• Record Type: Journal Article
• Authors: Klauke, Benedikt; Deckert, Jürgen; Zwanzger, Peter; Baumann, Christian; Arolt, Volker; Pauli, Paul; Reif, Andreas; Domschke, Katharina
• Is Part Of: World journal of biological psychiatry. Volume 15:Number 1(2014)
• Page Start: 17
• Page End: 25
• Publication Date: 2014-01
• Subjects: Biological psychiatry -- Periodicals; Biological Psychiatry -- Periodicals; 616.89
• DOI: 10.3109/15622975.2011.646302
• Languages: English
• ISSNs: 1562-2975

Abstract

<abstract> <title>Abstract</title> <p> <italic>Objectives.</italic> The pathogenesis of anxiety is assumed to be interactively influenced by genetic and environmental factors. Thus, a gene–environment interaction (G × E) study of the neuropeptide S receptor gene (<italic>NPSR</italic>) A/T polymorphism (rs324981) and life events was conducted with respect to anxiety sensitivity (AS) as an intermediate phenotype of anxiety disorders. <italic>Methods.</italic> A sample of 475 healthy German subjects was genotyped for <italic>NPSR</italic> and assessed for AS, childhood maltreatment (CTQ) and recent life events (LTE). Influences on AS and its subdimensions were determined by a step-wise hierarchical regression and a multiple indicator multiple cause (MIMIC) model. <italic>Results.</italic> Significant main effects of <italic>NPSR</italic> and CTQ as well as significant G × E were observed, with T/T homozygosity and a high CTQ score resulting in increased anxiety sensitivity. MIMIC modelling yielded association of AS subfactor "concern about mental/cognitive incapacitation" and the basal somatic subdimension "concern about physical sensations" to be associated with CTQ and its interaction with <italic>NPSR</italic>, while the acute somatic subfactor "concern about heart/lung failure" was associated with <italic>NPSR</italic> and its interaction with LTE. <italic>Conclusions.</italic> Results indicate G × E effects of the more active <italic>NPSR</italic> rs324981 T allele and life events on AS with differential effects of temporally proximal and distal factors on specific AS subdimensions.</p> </abstract>