TNFRSF11B polymorphisms are associated with metabolic traits in Uyghur and Han ethnic groups. (February 2014)

• Record Type: Journal Article
• Authors: Jiang, Xiao-Yan; Cai, Jian; Wang, Hong-Bao; Li, Xiang; Chen, Yan; Wang, Jing; Lin, Ren-Yong
• Is Part Of: Endocrine research. Volume 39:Number 1(2014:Feb.)
• Page Start: 34
• Page End: 38
• Publication Date: 2014-02
• Subjects: Endocrinology, Experimental -- Periodicals; Endocrinology -- Periodicals; Endocrinology -- Periodicals; Research -- Periodicals; 616.4
• DOI: 10.3109/07435800.2013.797433
• Languages: English
• ISSNs: 0743-5800

Abstract

<abstract> <title>Abstract</title> <p> <italic>Introduction</italic>: To test whether genetic variants of osteoprotegerin gene (TNFRSF11B) affect metabolic traits (body mass index [BMI], glucose, triglyceride, total cholesterol) and bone mass traits. <italic>Methods</italic>: We conducted a population based association study to investigate associations of eight tagging single nucleotide polymorphisms (tSNPs) of the TNFRSF11B gene with the aforementioned traits in a Chinese Han population and an ethnic group admixed with Caucasians and Asians – Uyghur. The associations between the tSNPs and bone mass density (BMD) were also tested in Han population. <italic>Results</italic>: We found that SNP rs3102727, located in the first intron of the TNFRSF11B gene, was significantly associated with triglyceride levels in Uyghur population and Han population simultaneously. T allele of the rs3102727 variant was associated with a 0.10 mmol/L and 0.09 mmol/L lower level of triglyceride than C allele in Uyghur (<italic>p</italic> = 0.019) and Han subjects (<italic>p</italic> = 0.037), respectively. In addition, the T allele is also associated with a lower level of hip BMD (<italic>p</italic> = 0.025) and total BMD (<italic>p</italic> = 0.048). Further, we found significant associations between SNP rs11573869 and BMI in Uyghur subjects and SNP rs3134062 with hip BMD in Han sbujects. Rs11573869-T allele was associated with a 0.81 kg/m<sup>2</sup> lower level of BMI than C allele (<italic>p</italic> = 0.002) and the hip BMD decreases with the copy of rs3134062-T allele increases (<italic>p</italic> = 0.002). <italic>Conclusion</italic>: We detected novel associations between TNFRSF11B polymorphisms and metabolic traits in Uyghur and Han populations. In addition, we found associations between TNFRSF11B polymorphisms and bone mass traits in Han population.</p> </abstract>