Raised Numbers of IgG4-Positive Plasma Cells Are a Common Histopathological Finding in Orbital Xanthogranulomatous Disease. (February 2014)

• Record Type: Journal Article
• Authors: Verdijk, Robert M.; Heidari, Pegah; Verschooten, Roel; van Daele, Paul L.; Simonsz, Huib J.; Paridaens, Dion
• Is Part Of: Orbit. Volume 33:Number 1(2014)
• Page Start: 17
• Page End: 22
• Publication Date: 2014-02
• Subjects: Eye-sockets -- Surgery -- Periodicals; Eye-sockets -- Diseases -- Periodicals; Orbit -- surgery -- Periodicals; Orbital Diseases -- Periodicals; 617.7
• DOI: 10.3109/01676830.2013.842252
• Languages: English
• ISSNs: 0167-6830

Abstract

<abstract> <title>ABSTRACT</title> <p> <italic>Purpose:</italic> To determine the relation of orbital xanthogranuloma with IgG4-related disease.</p> <p> <italic>Methods:</italic> Retrospective consecutive case series over a period of 25 years. We searched our charts for histologically confirmed orbital xanthogranuloma. Patient files were reviewed for clinical and follow up data including presence or absence of systemic non-ophthalmic manifestations of IgG4 related disease. Slides were re-examined and histopathological classification was re-assessed. Sixteen cases of orbital xanthogranuloma were evaluated. Immunohistochemical stains for IgG and IgG4 were performed. Positive immunohistochemical staining required increased IgG4-positive plasma cells in the involved tissues scored as &gt;50 per high-power field, with IgG4/IgG ratio &gt;0.40.</p> <p> <italic>Results:</italic> According to the criteria described above 8/16 (50%) cases showed increased numbers of IgG4-positive plasma cells in the specimens. Two of these patients may have had signs of systemic disease</p> <p> <italic>Conclusion:</italic> Raised numbers of IgG4-positive plasma cells are a common finding in histopathological specimens of xanthogranulomatous disease of the orbit and are often not indicative for IgG4 related systemic disease.</p> </abstract>