Effect of alpha lipoic acid on ifosfamide-induced central neurotoxicity in rats. (1st February 2014)

• Record Type: Journal Article
• Authors: Ozturk, Gulfer; Ginis, Zeynep; Kurt, Sefika Nur; Albayrak, Aynur; Bilen, Sule; Fadillioglu, Ersin
• Is Part Of: International journal of neuroscience. Volume 124:Number 2(2014:Feb.)
• Page Start: 110
• Page End: 116
• Publication Date: 2014-02-01
• Subjects: Nervous system -- Periodicals; 612.805
• DOI: 10.3109/00207454.2013.823962
• Languages: English
• ISSNs: 0020-7454

Abstract

<abstract> <title> <x xml:space="preserve">Abstract</x> </title> <p>Ifosfamide (IFOS) which is a cytotoxic alkylating agent may cause central nervous system toxicity. Alpha-lipoic acid (ALA) has a strong antioxidant effects. We hypothesized that ALA could attenuate on ifosfamide-induced central neurotoxicity in rats. Rats were divided into Control, IFOS, ALA and IFOS+ALA groups. The toxic effects of IFOS were analyzed by oxidative parameters and caspase 3 immunohistochemical examinations of brain tissue. The catalase activity of IFOS group significantly reduced in comparison with control groups ( <italic>p</italic> &lt; 0.05). The malondialdehyde (MDA) level and protein carbonyl (PC) content in brain tissue were significantly higher in IFOS group than in the other groups ( <italic>p</italic> &lt; 0.05). ALA treatments significantly prevented the increase in MDA level ( <italic>p</italic> &lt; 0.001) and PC content ( <italic>p</italic> &lt; 0.05) in brain tissue. IFOS group showed profound activation of caspase 3. The control, ALA and IFOS+ALA groups did not show caspase 3 activation. It was concluded that ALA treatments may have beneficial effects protecting neurons from central neurotoxicity caused by IFOS.</p> </abstract>