Regional and Voxel‐Wise Comparisons of Blood Flow Measurements Between Dynamic Susceptibility Contrast Magnetic Resonance Imaging (DSC‐MRI) and Arterial Spin Labeling (ASL) in Brain Tumors. Issue 1 (5th June 2012)

• Record Type: Journal Article
• Authors: White, Carissa M.; Pope, Whitney B.; Zaw, Taryar; Qiao, Joe; Naeini, Kourosh M.; Lai, Albert; Nghiemphu, Phioanh L.; Wang, J.J.; Cloughesy, Timothy F.; Ellingson, Benjamin M.
• Is Part Of: Journal of neuroimaging. Volume 24:Issue 1(2014)
• Page Start: 23
• Page End: 30
• Publication Date: 2012-06-05
• Subjects: Diagnostic imaging -- Periodicals; Nervous system -- Diseases -- Diagnosis -- Periodicals; Imagerie pour le diagnostic -- Périodiques; Système nerveux -- Maladies -- Diagnostic -- Périodiques; Imagerie médicale; Neuroimagerie; Neurologie; Système nerveux; Périodique électronique (Descripteur de forme); Ressource Internet (Descripteur de forme); 616.804754
• DOI: 10.1111/j.1552-6569.2012.00703.x
• Languages: English
• ISSNs: 1051-2284

Abstract

<abstract abstract-type="main"> <title>ABSTRACT</title> <p>The objective of the current study was to evaluate the regional and voxel‐wise correlation between dynamic susceptibility contrast (DSC) and arterial spin labeling (ASL) perfusion magnetic resonance imaging (MRI) measurement of cerebral blood flow (CBF) in patients with brain tumors. Thirty patients with histologically verified brain tumors were evaluated in the current study. DSC‐MRI was performed by first using a preload dose of gadolinium contrast, then collecting a dynamic image acquisition during a bolus of contrast, followed by posthoc contrast agent leakage correction. Pseudocontinuous ASL was collected using 30 pairs of tag and control acquisition using a 3‐dimensional gradient‐echo spin‐echo (GRASE) acquisition. All images were registered to a high‐resolution anatomical atlas. Average CBF measurements within regions of contrast‐enhancement and T2 hyperintensity were evaluated between the two modalities. Additionally, voxel‐wise correlation between CBF measurements obtained with DSC and ASL were assessed. Results demonstrated a positive linear correlation between DSC and ASL measurements of CBF when regional average values were compared; however, a statistically significant voxel‐wise correlation was only observed in around 30‐40% of patients. These results suggest DSC and ASL may provide regionally similar, but spatially different measurements of CBF.</p> </abstract>