Neopterin is associated with cardiovascular events and all‐cause mortality in renal transplant patients. (24th December 2013)

• Record Type: Journal Article
• Authors: Pihlstrøm, Hege; Mjøen, Geir; März, Winfried; Olav Dahle, Dag; Abedini, Sadollah; Holme, Ingar; Fellström, Bengt; Jardine, Alan; Pilz, Stefan; Holdaaas, Hallvard
• Is Part Of: Clinical transplantation. Volume 28:Number 1(2014:Jan./Feb.)
• Page Start: 111
• Page End: 119
• Publication Date: 2013-12-24
• Subjects: Transplantation of organs, tissues, etc -- Periodicals; 617.95
• DOI: 10.1111/ctr.12285
• Languages: English
• ISSNs: 0902-0063

Abstract

<abstract abstract-type="main" id="ctr12285-abs-0001"> <title>Abstract</title> <sec id="ctr12285-sec-0001" sec-type="section"> <title>Background</title> <p>Inflammatory markers show significant associations with cardiovascular events and all‐cause mortality after kidney transplantation. Neopterin, reflecting interferon‐γ‐release, may better reflect the proinflammatory state of recipients than less specific markers.</p> </sec> <sec id="ctr12285-sec-0002" sec-type="section"> <title>Methods</title> <p>Kidney transplant recipients in the Assessment of LEscol in Renal Transplant (ALERT) trial were examined and investigated for an association between serum neopterin and subsequent clinical events: graft loss, major cardiovascular events (MACE) and all‐cause mortality.</p> </sec> <sec id="ctr12285-sec-0003" sec-type="section"> <title>Results</title> <p>After adjustment for established and emerging risk factors neopterin expressed as neopterin‐to‐creatinine ratio was significantly associated with MACE (p = 0.009) and all‐cause mortality (p = 0.002). Endpoints were more frequent with increasing quartiles of neopterin‐to‐creatinine ratio. The incidence rates of MACE and all‐cause mortality were significantly increased in the upper quartiles compared with the first.</p> </sec> <sec id="ctr12285-sec-0004" sec-type="section"> <title>Conclusions</title> <p>This long‐term prospective analysis in stable kidney allograft recipients suggests that neopterin is associated with long‐term risk of cardiovascular events and all‐cause mortality, but not renal outcomes.</p> </sec> </abstract>