Spirometric reference values for healthy nonsmoking Saudi adults. (31st July 2013)

• Record Type: Journal Article
• Authors: Al Ghobain, Mohammed O.; Alhamad, Esam H.; Alorainy, Hassan S.; Al Hazmi, Manal; Al Moamary, Mohamed S.; Al‐Hajjaj, Mohamed S.; Idress, Majdy; Al‐Jahdali, Hamdan; Zeitouni, Mohammed
• Is Part Of: Clinical respiratory journal. Volume 8:Number 1(2014)
• Page Start: 72
• Page End: 78
• Publication Date: 2013-07-31
• Subjects: Respiratory organs -- Diseases -- Periodicals; Respiratory organs -- Periodicals; 616.24
• DOI: 10.1111/crj.12038
• Languages: English
• ISSNs: 1752-6981

Abstract

<abstract abstract-type="main"> <title>Abstract</title> <sec id="crj12038-sec-0002" sec-type="section"> <title>Objectives</title> <p>To derive prediction equations of spirometric values of healthy Saudi adults and to compare the derived equations with equations reported in selected population.</p> </sec> <sec id="crj12038-sec-0003" sec-type="section"> <title>Methods</title> <p>Cross‐sectional study of healthy nonsmoking men and women Saudi adults. The measured spirometric values were the forced vital capacity (FVC), forced expiratory volume in 1 s (FEV<sub>1</sub>), peak expiratory flow (PEF) and forced mid‐expiratory flow (FEF 25%–75%).</p> </sec> <sec id="crj12038-sec-0004" sec-type="section"> <title>Results</title> <p>A total of 621 spirometric tests were done. The prediction equations were derived using the following formula: Predicted spirometric value = constant + (b1 × age) + (b2 × height (cm)), where b1 and b2 represent the regression coefficients for age and height, respectively.</p> <p> <table-wrap position="anchor" orientation="portrait"> <label> <x xml:space="preserve">Table </x> </label> <table border="1"> <colgroup span="1"> <col align="left" span="1" /> <col align="left" span="1" /> <col align="left" span="1" /> <col align="left" span="1" /> <col align="left" span="1" /> <col align="left" span="1" /> <col align="left" span="1" /> <col align="left" span="1" /> </colgroup> <thead> <tr> <th align="left" rowspan="1" colspan="1">Variable</th> <th align="left" rowspan="1" colspan="1">Constant</th> <th align="left" rowspan="1" colspan="1">Age (years)</th> <th align="left" rowspan="1" colspan="1">Height (cm)</th> <th align="left" rowspan="1" colspan="1">Variable</th> <th align="left" rowspan="1" colspan="1">Constant</th> <th align="left" rowspan="1" colspan="1">Age (years)</th> <th align="left" rowspan="1" colspan="1">Height (cm)</th> </tr> </thead> <tbody> <tr> <td align="left" rowspan="1" colspan="1">Males (<italic>n</italic> = 292)</td> <td align="left" rowspan="1" colspan="1"> </td> <td align="left" rowspan="1" colspan="1"> </td> <td align="left" rowspan="1" colspan="1"> </td> <td align="left" rowspan="1" colspan="1">Females (<italic>n</italic> = 175)</td> <td align="left" rowspan="1" colspan="1"> </td> <td align="left" rowspan="1" colspan="1"> </td> <td align="left" rowspan="1" colspan="1"> </td> </tr> <tr> <td align="left" rowspan="1" colspan="1">FVC</td> <td align="left" rowspan="1" colspan="1">−2.933</td> <td align="left" rowspan="1" colspan="1">−0.018</td> <td align="left" rowspan="1" colspan="1">0.046</td> <td align="left" rowspan="1" colspan="1">FVC</td> <td align="left" rowspan="1" colspan="1">−3.470</td> <td align="left" rowspan="1" colspan="1">−0.016</td> <td align="left" rowspan="1" colspan="1">0.045</td> </tr> <tr> <td align="left" rowspan="1" colspan="1">FEV<sub>1</sub></td> <td align="left" rowspan="1" colspan="1">−1.886</td> <td align="left" rowspan="1" colspan="1">−0.019</td> <td align="left" rowspan="1" colspan="1">0.036</td> <td align="left" rowspan="1" colspan="1">FEV<sub>1</sub></td> <td align="left" rowspan="1" colspan="1">−2.482</td> <td align="left" rowspan="1" colspan="1">−0.018</td> <td align="left" rowspan="1" colspan="1">0.036</td> </tr> <tr> <td align="left" rowspan="1" colspan="1">FEV<sub>1</sub>/FVC (%)</td> <td align="left" rowspan="1" colspan="1">98.41</td> <td align="left" rowspan="1" colspan="1">−0.095</td> <td align="left" rowspan="1" colspan="1">−0.068</td> <td align="left" rowspan="1" colspan="1">FEV<sub>1</sub>/FVC (%)</td> <td align="left" rowspan="1" colspan="1">100.67</td> <td align="left" rowspan="1" colspan="1">−0.142</td> <td align="left" rowspan="1" colspan="1">−0.072</td> </tr> <tr> <td align="left" rowspan="1" colspan="1">PEF</td> <td align="left" rowspan="1" colspan="1">17.274</td> <td align="left" rowspan="1" colspan="1">−1.243</td> <td align="left" rowspan="1" colspan="1">3.471</td> <td align="left" rowspan="1" colspan="1">PEF</td> <td align="left" rowspan="1" colspan="1">−226.648</td> <td align="left" rowspan="1" colspan="1">−0.499</td> <td align="left" rowspan="1" colspan="1">4.076</td> </tr> <tr> <td align="left" rowspan="1" colspan="1">FEF25%–75%</td> <td align="left" rowspan="1" colspan="1">0.100</td> <td align="left" rowspan="1" colspan="1">−0.024</td> <td align="left" rowspan="1" colspan="1">0.027</td> <td align="left" rowspan="1" colspan="1">FEF25%−75%</td> <td align="left" rowspan="1" colspan="1">−1.337</td> <td align="left" rowspan="1" colspan="1">−0.021</td> <td align="left" rowspan="1" colspan="1">0.031</td> </tr> </tbody> </table> </table-wrap> </p> <p>The means of the measured FVC and FEV<sub>1</sub> were significantly lower than the predicted values derived by the American equations of −7.2% and −4.6% among males, respectively (<italic>P</italic> value < 0.00001), and −4.7%, and −5.26% among females, respectively (<italic>P</italic> value < 0.00001).</p> </sec> <sec id="crj12038-sec-0005" sec-type="section"> <title>Conclusion</title> <p>The reference spirometric values derived in our study were significantly lower than the predicted values derived by the American equations.</p> </sec> </abstract>