Nocturnal blood pressure non‐dipping is prevalent in severely obese, prepubertal and early pubertal children. (3rd December 2013)

• Record Type: Journal Article
• Authors: Westerståhl, M; Hedvall Kallerman, P; Hagman, E; Ek, A E; Rössner, S M; Marcus, C
• Is Part Of: Acta pædiatrica. Volume 103:Number 2(2014:Feb.)
• Page Start: 225
• Page End: 230
• Publication Date: 2013-12-03
• Subjects: Pediatrics -- Periodicals; Pediatrics; 618.92
• DOI: 10.1111/apa.12479
• Languages: English
• ISSNs: 0803-5253

Abstract

<abstract abstract-type="main" id="apa12479-abs-0001"> <title>Abstract</title> <sec id="apa12479-sec-0001" sec-type="section"> <title>Aim</title> <p>To investigate the prevalence of nocturnal blood pressure dipping among obese prepubertal and early pubertal children and to analyse the relationship between dipping and measures of insulin‐glucose metabolism or sleep‐disordered breathing.</p> </sec> <sec id="apa12479-sec-0002" sec-type="section"> <title>Methods</title> <p>We studied 76 obese children (41% girls) under clinical care, with an average age of 10.4 ± 1.7 and a body mass index Z‐score (BMI Z‐score) of 6.2 ± 1.6. We performed a 24‐h ambulatory blood pressure measurement. Non‐dipping was defined as a nocturnal blood pressure reduction of <10%. We calculated measures of insulin‐glucose metabolism from the performed frequently sampled intravenous glucose‐tolerance test and from fasting blood samples. Overnight sleep polygraph recordings were performed to assess sleep‐disordered breathing.</p> </sec> <sec id="apa12479-sec-0003" sec-type="section"> <title>Results</title> <p>Forty‐two percent of the children were systolic non‐dippers, and 17% were diastolic non‐dippers. There were no associations between systolic or diastolic dipping and measures of insulin‐glucose metabolism after adjustments for BMI Z‐score, gender and pubertal status. There were no associations between dipping and measures of sleep‐disordered breathing.</p> </sec> <sec id="apa12479-sec-0004" sec-type="section"> <title>Conclusion</title> <p>Nocturnal non‐dipping was two times higher among severely obese, prepubertal and early pubertal children, compared to previous reports among children in general. There were no associations between nocturnal dipping and insulin‐glucose metabolism or measures of sleep‐disordered breathing in this group.</p> </sec> </abstract>