"Axitinib Affects Cell Viability and Migration of a Primary Foetal Lung Adenocarcinoma Culture". (2nd January 2014)

• Record Type: Journal Article
• Authors: Menna, Cecilia; De Falco, Elena; Pacini, Luca; Scafetta, Gaia; Ruggieri, Paola; Puca, Rosa; Petrozza, Vincenzo; Ciccone, Anna Maria; Rendina, Erino Angelo; Calogero, Antonella; Ibrahim, Mohsen
• Is Part Of: Cancer investigation. Volume 32:Number 1(2014)
• Page Start: 13
• Page End: 21
• Publication Date: 2014-01-02
• Subjects: Cancer -- Periodicals; Oncology -- Periodicals; Medical Oncology -- Periodicals; Neoplasms -- Periodicals; 616.994
• DOI: 10.3109/07357907.2013.861472
• Languages: English
• ISSNs: 0735-7907

Abstract

<abstract> <title> <x xml:space="preserve">Abstract</x> </title> <p>Fetal lung adenocarcinoma (FLAC) is a rare variant of lung adenocarcinoma. Studies regarding FLAC have been based only on histopathological observations, thus representative <italic>in vitro</italic> models of FLAC cultures are unavailable. We have established and characterized a human primary FLAC cell culture, exploring its biology, chemosensitivity, and migration. FLAC cells and specimen showed significant upregulation of VEGF₁₆₅ and HIF-1α mRNA levels. This observation was confirmed by <italic>in vitro</italic> chemosensitivity and migration assay, showing that only Axitinib was comparable to Cisplatin treatment. We provide a suitable <italic>in vitro</italic> model to further investigate the nature of this rare type of cancer.</p> </abstract>