Confined placental mosaicism: implications for fetal chromosomal analysis using microarray comparative genomic hybridization. (14th November 2013)

• Record Type: Journal Article
• Authors: Karampetsou, Evangelia; Morrogh, Deborah; Ballard, Terry; Waters, Jonathan J.; Lench, Nicholas; Chitty, Lyn S.
• Is Part Of: Prenatal diagnosis. Volume 34:Number 1(2014:Jan.)
• Page Start: 98
• Page End: 101
• Publication Date: 2013-11-14
• Subjects: Prenatal diagnosis -- Periodicals; Fetus -- Diseases -- Diagnosis -- Periodicals; Electronic journals; 618.32075
• DOI: 10.1002/pd.4255
• Languages: English
• ISSNs: 0197-3851

Abstract

<abstract abstract-type="short"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>What's already known about this topic?</bold> <list id="pd4255-list-0001" list-type="bullet"> <list-item id="pd4255-li-0001"> <p>Use of microarray for prenatal diagnosis increases the detection of pathogenic chromosomal rearrangements.</p> </list-item> <list-item id="pd4255-li-0002"> <p>CPM is a well‐established phenomenon occurring in 1–2% of CVS.</p> </list-item> </list> </p> <p> <bold>What does this study add?</bold> <list id="pd4255-list-0002" list-type="bullet"> <list-item id="pd4255-li-0003"> <p>CPM can occur for submicroscopic copy number changes detected by array CGH in DNA from uncultured CVS. In order to minimise the risk of false‐positive results in these cases, detected copy number changes should be confirmed in a different source of material, such as cultured cells.</p> </list-item> </list> </p> </abstract>