Detection of S100B in maternal blood before and after fetal death. (January 2014)

• Record Type: Journal Article
• Authors: Beharier, Ofer; Shusterman, Eden; Eshcoli, Tamar; Szaingurten‐Solodkin, Irit; Aricha‐Tamir, Barak; Weintraub, Adi Y.; Sheiner, Eyal; Holcberg, Gershon; Hershkovitz, Reli
• Is Part Of: Prenatal diagnosis. Volume 34:Number 1(2014:Jan.)
• Page Start: 94
• Page End: 97
• Publication Date: 2014-01
• Subjects: Prenatal diagnosis -- Periodicals; Fetus -- Diseases -- Diagnosis -- Periodicals; Electronic journals; 618.32075
• DOI: 10.1002/pd.4266
• Languages: English
• ISSNs: 0197-3851

Abstract

<abstract abstract-type="main"> <title>ABSTRACT</title> <sec id="pd4266-sec-0001" sec-type="section"> <title>Background</title> <p>S100B is a brain damage biomarker. When measured immediately after birth, it reflects neonatal brain damage following asphyxia. In this study, we used feticide as a novel model of fetal brain damage. We examined whether such damage is reflected by a rise in S100B in maternal blood before delivery.</p> </sec> <sec id="pd4266-sec-0002" sec-type="section"> <title>Methods</title> <p>Eight pregnant women were recruited between January and July 2012. Maternal blood samples were drawn before and after feticide at predetermined time points (0, 15, 30, 60, 120, and 240 min). S100B, lactate dehydrogenase, creatine kinase, and creatinine concentrations were measured by standard human ELISA and chemical analyzer.</p> </sec> <sec id="pd4266-sec-0003" sec-type="section"> <title>Results</title> <p>No significant difference was noted between S100B levels before and after feticide, neither in non‐specific cell death markers (lactate dehydrogenase and creatine kinase), which remained within normal range. S100B ranged between 0.015–0.04 µg/L through all the predetermined time points.</p> </sec> <sec id="pd4266-sec-0004" sec-type="section"> <title>Conclusion</title> <p>No statistically significant differences were demonstrated in S100B levels before and after feticide. © 2013 John Wiley &amp; Sons, Ltd.</p> </sec> </abstract>