Epidemiology of sinonasal squamous cell carcinoma: A comprehensive analysis of 4994 patients. (1st July 2013)

• Record Type: Journal Article
• Authors: Sanghvi, Saurin; Khan, Mohemmed N.; Patel, Neal R.; Yeldandi, Swetha; Baredes, Soly; Eloy, Jean Anderson
• Is Part Of: Laryngoscope. Volume 124:Number 1(2014:Jan.)
• Page Start: 76
• Page End: 83
• Publication Date: 2013-07-01
• Subjects: Otolaryngology -- Periodicals; 617.51005
• DOI: 10.1002/lary.24264
• Languages: English
• ISSNs: 0023-852X

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="lary24264-sec-0001" sec-type="section"> <title>Objectives/Hypothesis</title> <p>To examine the incidence and survival of patients with sinonasal squamous cell carcinoma (SNSCC) between the years of 1973 and 2009 using the Surveillance, Epidemiology, and End Result (SEER) database.</p> </sec> <sec id="lary24264-sec-0002" sec-type="section"> <title>Study Design</title> <p>Retrospective cohort study using a national database.</p> </sec> <sec id="lary24264-sec-0003" sec-type="section"> <title>Methods</title> <p>The SEER registry was utilized to calculate incidence and survival trends for patients with SNSCC between 1973 and 2009. Patient data were then analyzed according to age, sex, and race.</p> </sec> <sec id="lary24264-sec-0004" sec-type="section"> <title>Results</title> <p>A total of 4, 994 cases of SNSCC were identified, composed of 64.44% males and 35.56% females. Incidence trend analysis revealed a significant decrease in yearly rates from 1973 to 2009 for the overall population, females, whites, blacks, and "others" (<italic>P</italic> < .05). Overall 5‐, 10‐, and 20‐year survival for SNSCC was 52.95%, 44.67%, and 29.37%, respectively. No significant differences (<italic>P</italic> > .05) were found when comparing survival between the last three decades. Differences in long‐term survival were noted between whites, blacks, and "others, " with whites displaying the highest 20‐year survival. Males and females were found to have similar long‐term survival curves, with 20‐year survival of 30.68% and 26.35%, respectively.</p> </sec> <sec id="lary24264-sec-0005" sec-type="section"> <title>Conclusions</title> <p>The overall incidence of SNSCC is declining. However, survival has not significantly improved in the last 3 decades. Race seems to influence the overall survival of this tumor. Future studies need to be conducted to investigate these dynamic trends related to SNSCC.</p> </sec> <sec id="lary24264-sec-0006" sec-type="section"> <title>Level of Evidence</title> <p>2b. <italic>Laryngoscope</italic>, 124:76–83, 2014</p> </sec> </abstract>