One‐step radiosynthesis of 4‐nitrophenyl 2‐[18F]fluoropropionate ([18F]NFP); improved preparation of radiolabeled peptides for PET imaging. (16th September 2013)

• Record Type: Journal Article
• Authors: Haskali, Mohammad B.; Roselt, Peter D.; Karas, John A.; Noonan, Wayne; Wichmann, Christian W.; Katsifis, Andrew; Hicks, Rodney J.; Hutton, Craig A.
• Is Part Of: Journal of labelled compounds & radiopharmaceuticals. Volume 56:Number 14(2013)
• Page Start: 726
• Page End: 730
• Publication Date: 2013-09-16
• Subjects: Tracers (Chemistry) -- Periodicals; Radiopharmaceuticals -- Periodicals; 615.8424
• DOI: 10.1002/jlcr.3111
• Languages: English
• ISSNs: 0362-4803

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <p>The versatile ¹⁸F‐labeled prosthetic group, 4‐nitrophenyl 2‐[¹⁸F]fluoropropionate ([¹⁸F]NFP), was synthesized in a single step in 45 min from 4‐nitrophenyl 2‐bromopropionate, with a decay corrected radiochemical yield of 26.2% ± 2.2%. Employing this improved synthesis of [¹⁸F]NFP, [¹⁸F]GalactoRGD — the current 'gold standard' tracer for imaging the expression of <italic>α</italic>_V<italic>β</italic>₃ integrin — was prepared with high specific activity in 90 min and 20% decay corrected radiochemical yield from [¹⁸F]fluoride.</p> </abstract>