Increase of peripheral blood TCD8+ cells in women with recurrent miscarriage. (January 2014)

• Record Type: Journal Article
• Authors: Ghafourian, M.; Abuhamidy, A.; Karami, N.
• Is Part Of: Journal of obstetrics and gynaecology. Volume 34:Number 1(2014)
• Page Start: 36
• Page End: 39
• Publication Date: 2014-01
• Subjects: Obstetrics -- Periodicals; Gynecology -- Periodicals; 618.05
• DOI: 10.3109/01443615.2013.817980
• Languages: English
• ISSNs: 0144-3615

Abstract

<abstract> <title> <x xml:space="preserve">Abstract</x> </title> <p>Recurrent miscarriage (RM) is one of the most prevalent reproductive problems faced by couples that may affect as many as 2% of women in reproductive age. The causes of its abnormality have attracted the attention of many researchers. We aim to determine the different T-cell subsets in women with RM and normal control. In this prospective case–control study, peripheral blood was taken from women with RM (<italic>n</italic> = 25) and normal women (<italic>n</italic> = 17), during the mid-luteal phase. The percentage of CD3, CD3⁺CD4⁺, CD3⁺CD8⁺ markers and also CD4/CD8 ratio was detected in the patients and control group by flow cytometry. The proportion of TCD8⁺ was significantly higher in RM women compared with the control group (<italic>p &lt; </italic>0.05). However, there was no statistical difference in percentage of total TCD3⁺ and TCD4⁺ cells between the RM and control women. Also, the CD4/CD8 ratio was lower in the RM women compared with the control women. These observations support the concept that increase of TCD8⁺ lymphocytes could be involved in the aetiology of RM.</p> </abstract>