Comparison of performance status with peak oxygen consumption in operable patients with non‐small‐cell lung cancer. Issue 1 (January 2014)

• Record Type: Journal Article
• Authors: Roman, Michael A.; Koelwyn, Graeme J.; Eves, Neil D.; Hornsby, Whitney E.; Watson, Dorothy; Herndon II, James E.; Kohman, Leslie; Loewen, Gregory; Jones, Lee W.
• Is Part Of: Respirology. Volume 19:Issue 1(2014)
• Page Start: 105
• Page End: 108
• Publication Date: 2014-01
• Subjects: Respiratory organs -- Diseases -- Periodicals; Respiratory organs -- Periodicals; 612.2
• DOI: 10.1111/resp.12162
• Languages: English
• ISSNs: 1323-7799

Abstract

<abstract abstract-type="main"> <title>Abstract</title> <sec id="resp12162-sec-0001" sec-type="section"> <title>Background and objective</title> <p>In this era of increasing options for treatment of 'surgical' lung cancer patients, preoperative physiologic assessment of accurate patient selection is becoming more important. The variability in an objective measure of cardiorespiratory fitness (peak oxygen consumption (VO<sub>2peak</sub>)) across performance in operable non‐small‐cell lung cancer (NSCLC) patients enrolled in the Cancer and Leukemia Group B trial was compared.</p> </sec> <sec id="resp12162-sec-0002" sec-type="section"> <title>Methods</title> <p>Using a cross‐sectional design, 392 NSCLC patients underwent an incremental cardiopulmonary cycling exercise test to symptom limitation with expired gas analysis to determine VO<sub>2peak</sub>. Performance status (PS) was assessed using the Eastern Cooperative Oncology Group (ECOG) tool.</p> </sec> <sec id="resp12162-sec-0003" sec-type="section"> <title>Results</title> <p>There was a significant decrease in VO<sub>2peak</sub> across increasing ECOG categories (<italic>P</italic> < 0.0001). However, there was a large range in VO<sub>2peak</sub> for any given ECOG category with overlap between categories (ECOG 0: 5.0–31.5 mL/kg/min; ECOG 1: 4.3–24.8 mL/kg/min; ECOG 2: 8.9–21.9 mL/kg/min; ECOG 3; 3.3–11.7 mL/kg/min).</p> </sec> <sec id="resp12162-sec-0004" sec-type="section"> <title>Conclusions</title> <p>PS scoring systems do not provide a sensitive measure of functional status. Objective measures such as VO<sub>2peak</sub> may be a useful in the clinical management of oncology patients.</p> </sec> </abstract>