QCM‐4 a novel 5‐HT3 antagonist attenuates the behavioral and biochemical alterations on chronic unpredictable mild stress model of depression in Swiss albino mice. (4th November 2013)

• Record Type: Journal Article
• Authors: Kurhe, Yeshwant; Radhakrishnan, Mahesh; Gupta, Deepali; Devadoss, Thangaraj
• Is Part Of: Journal of pharmacy and pharmacology. Volume 66:Number 1(2014:Jan.)
• Page Start: 122
• Page End: 132
• Publication Date: 2013-11-04
• Subjects: Pharmacy -- Periodicals; Pharmacology -- Periodicals; 615.1
• DOI: 10.1111/jphp.12163
• Languages: English
• ISSNs: 0022-3573

Abstract

<abstract abstract-type="main"> <title>Abstract</title> <sec id="jphp12163-sec-0001" sec-type="section"> <title>Objectives</title> <p>The inconsistent therapeutic outcome necessitates identifying novel compounds for the treatment of depression. Therefore, the present study is aimed at evaluating the antidepressant‐like effects of a novel 5‐HT<sub>3</sub> receptor antagonist 3‐methoxy‐<italic>N</italic>‐<italic>p‐</italic>tolylquinoxalin‐2‐carboxamide (QCM‐4) on chronic unpredictable mild stress (CUMS) induced behavioral and biochemical alterations in mice.</p> </sec> <sec id="jphp12163-sec-0002" sec-type="section"> <title>Methods</title> <p>Animals were subjected to different stressors for a period of 28 days. Thereafter, battery tests like locomotor score, sucrose preference test, forced swim test (FST), tail suspension test (TST), elevated plus maze (EPM) and open field test (OFT) were performed. Biochemical assays like lipid peroxidation, nitrite levels, reduced glutathione (GSH), catalase and superoxide dismutase (SOD) were assessed in brain homogenate.</p> </sec> <sec id="jphp12163-sec-0003" sec-type="section"> <title>Key findings</title> <p>QCM‐4 dose dependently reversed the CUMS induced behavioral and biochemical alterations by increasing the sucrose consumption, reducing the immobility time in FST and TST, increasing the percent time in open arm in EPM and increasing the ambulation along with the rearings and decreased number of fecal pellets in OFT. Further, biochemical alterations were attenuated by QCM‐4 as indicated by reduced lipid peroxidation and nitrite levels and elevated antioxidant enzyme levels like GSH, catalase and SOD.</p> </sec> <sec id="jphp12163-sec-0004" sec-type="section"> <title>Conclusions</title> <p>QCM‐4 attenuated the behavioral and biochemical derangements induced by CUMS in mice, indicating antidepressant behavior of the novel compound.</p> </sec> </abstract>