Characteristics of girls with pituitary hyperplasia and sexual precocity secondary to primary hypothyroidism. (11th November 2013)

• Record Type: Journal Article
• Authors: Hu, Yan‐Yan; Li, Gui‐Mei; Hu, Wen‐Wen; Wang, Yi
• Is Part Of: Acta pædiatrica. Volume 103:Number 1(2014:Jan.)
• Page Start: e43
• Page End: e48
• Publication Date: 2013-11-11
• Subjects: Pediatrics -- Periodicals; Pediatrics; 618.92
• DOI: 10.1111/apa.12444
• Languages: English
• ISSNs: 0803-5253

Abstract

<abstract abstract-type="main" id="apa12444-abs-0001"> <title>Abstract</title> <sec id="apa12444-sec-0001" sec-type="section"> <title>Aim</title> <p>To investigate the different characteristics of girls with pituitary hyperplasia secondary to primary hypothyroidism (PPH), with and without sexual precocity.</p> </sec> <sec id="apa12444-sec-0002" sec-type="section"> <title>Methods</title> <p>Pituitary hyperplasia secondary to primary hypothyroidism girls were divided into two groups: group A, with sexual precocity (n = 8), and group B, without sexual precocity (n = 14). The following values were measured before and after 3 months levothyroxine therapy: free triiodothyronine (FT<sub>3</sub>), free thyroxine (FT<sub>4</sub>), thyrotropin (TSH), follicle‐stimulating hormone (FSH), luteinising hormone (LH), prolactin (PRL), estradiol (E<sub>2</sub>), testosterone (T), pituitary height, uterine volume (UV), ovarian volume (OV) and follicular diameter (FD).</p> </sec> <sec id="apa12444-sec-0003" sec-type="section"> <title>Results</title> <p>Thyrotropin, FSH, PRL, E<sub>2</sub>, T, pituitary height, UV, OV and FD were higher in group A than group B (all p < 0.05); FT<sub>3</sub>, FT<sub>4</sub> and LH levels were not different (all p > 0.05). In all of the PPH girls, pituitary height was correlated with FT<sub>3</sub>, FT<sub>4</sub> and PRL (r = −0.545, p = 0.009, r = −0.567, p = 0.006 and r = 0.666, p = 0.001, respectively). PRL was positively correlated with UV, FD and FSH (r = 0.581, p = 0.005, r = 0.482, p = 0.031 and r = 0.667, p = 0.001, respectively), and FSH was positively correlated with OV (r = 0.522, p = 0.013). These abnormalities regressed after therapy.</p> </sec> <sec id="apa12444-sec-0004" sec-type="section"> <title>Conclusion</title> <p>Pituitary hyperplasia secondary to primary hypothyroidism girls with sexual precocity have increased plasma TSH, FSH, PRL, E<sub>2</sub> and T levels, pituitary height and uterine, ovarian and follicular size.</p> </sec> </abstract>