Curcumin loaded electrospun Bombyx mori silk nanofibers for drug delivery. Issue 1 (12th April 2013)

• Record Type: Journal Article
• Authors: Elakkiya, Thangaraju; Malarvizhi, Govindaswamy; Rajiv, Sheeja; Natarajan, Thirupathur Srinivasan
• Is Part Of: Polymer international. Volume 63:Issue 1(2014:Jan.)
• Page Start: 100
• Page End: 105
• Publication Date: 2013-04-12
• Subjects: Plastics -- Periodicals; Polymers -- Periodicals; Polymerization -- Periodicals; 547.7
• DOI: 10.1002/pi.4499
• Languages: English
• ISSNs: 0959-8103

Abstract

<abstract abstract-type="main"> <title>Abstract</title> <p> <bold>Silk fibroin from <italic>Bombyx mori</italic> silk cocoons was electrospun into silk nanofibers (SNFs). SEM images show that 9% w/v of SNFs was smooth and beadless having an average diameter in the range 30–150 nm. Curcumin (0.5–1.5 wt%) was incorporated into the silk fibroin solution and electrospun to obtain curcumin incorporated silk nanofibers (CSNFs) with diameters between 50 and 200 nm. The dispersion of curcumin in the SNFs was confirmed by TEM. The amorphous nature of curcumin upon incorporation into SNFs was confirmed by XRD. The functional groups of SNF and CSNF were confirmed by Fourier transform infrared spectroscopy. The SNFs and CSNFs were thermally stable up to <italic>ca</italic> 350 °C as evidenced by TGA. The glass transition temperature (<italic>T</italic>_g) of SNFs (168 °C) increased to 184 °C in the case of CSNFs as confirmed by DSC. The storage modulus, loss modulus and tan δ were determined by dynamic mechanical analysis. The percentages of porosity and water uptake of SNFs were 85% and 150%, respectively. The percentage <italic>in vitro</italic> cumulative release of curcumin at the end of the tenth day for 0.5, 1 and 1.5 wt% formulations was 82%, 84% and 80%, respectively. © 2013 Society of Chemical Industry</bold> </p> </abstract>