High encapsulation efficiency of poloxamer-based injectable thermoresponsive hydrogels of etoposide. (September 2014)

• Record Type: Journal Article
• Authors: Soni, Govind; Yadav, Khushwant S.
• Is Part Of: Pharmaceutical development and technology. Volume 19:Number 6(2014)
• Page Start: 651
• Page End: 661
• Publication Date: 2014-09
• Subjects: Drug delivery systems -- Periodicals; Pharmaceutical technology -- Periodicals; Drugs -- Administration -- Research -- Periodicals; Drug Delivery Systems -- Periodicals; Pharmaceutical Preparations -- Periodicals; Technology, Pharmaceutical -- Periodicals; 615
• DOI: 10.3109/10837450.2013.819014
• Languages: English
• ISSNs: 1083-7450

Abstract

<abstract> <title>Abstract</title> <p> <italic>Context</italic>: Hydrogels are promising polymeric network capable of sustaining the release of drug but have a major limitation for encapsulation of hydrophobic drugs.</p> <p> <italic>Objective</italic>: This study was undertaken to encapsulate etoposide in poloxamer 407-based thermosensitive hydrogels with an aim to sustain its release.</p> <p> <italic>Materials and methods</italic>: Etoposide-loaded hydrogels were prepared by the cold method and optimized for encapsulation efficiency (EE) by a 3² factorial design. Poloxamer 407-poloxamer 188 hydrogel (E-P407-P188) and poloxamer 407-poly(ethylene glycol) (E-P407-PEG) hydrogel were characterized for SEM, swelling, sol–gel phase transition and injectability study.</p> <p> <italic>Results and discussion</italic>: In E-P407-P188 hydrogel the EE of 75% could be obtained and in E-P407-PEG hydrogels the EE was 84%. The SEM images showed a porous structure. The release of ETO was sustained up to 48 h by E-P407-PEG hydrogel and 24 h by E-P407-P188 hydrogel. The drug release was governed by first-order kinetics and followed Fickian diffusion mechanism in both the cases.</p> <p> <italic>Conclusion</italic>: Such injectable thermosensitive hydrogel of etoposide could be effectively used for continuous release of drug to the tumor and surrounding tissues.</p> </abstract>