Comparison between taxane-based chemotherapy with conventional surgery-based therapy for cutaneous angiosarcoma: a single-center experience. (October 2014)

• Record Type: Journal Article
• Authors: Fujisawa, Yasuhiro; Nakamura, Yasuhiro; Kawachi, Yasuhiro; Otsuka, Fujio
• Is Part Of: Journal of dermatological treatment. Volume 25:Number 5(2014:Oct.)
• Page Start: 419
• Page End: 423
• Publication Date: 2014-10
• Subjects: Skin -- Diseases -- Treatment -- Periodicals; Skin Diseases -- drug therapy -- Periodicals; Skin Diseases -- therapy -- Periodicals; 616.5
• DOI: 10.3109/09546634.2012.754839
• Languages: English
• ISSNs: 0954-6634

Abstract

<abstract> <title /> <p> <italic>Objective</italic>:To show the efficacy of taxane-based chemotherapy for the treatment of cutaneous angiosarcoma. <italic>Methods: </italic>A case–control study comparing patients who received taxanes without wide local excision (group A, <italic>n</italic> = 5) and patients who received conventional surgery-based therapy (group B, <italic>n</italic> = 8) in one university hospital in eastern Japan. Data were collected from a total of 13 patients with cutaneous angiosarcoma treated from November 1997 through July 2009. <italic>Results</italic>:Group A received taxanes: four patients received docetaxel, and one patient received paclitaxel. Radiation was used concomitantly in two patients. Marginal local excision was performed in two patients. Group B received wide local excision followed by radiation (six patients), docetaxel (three patients), and interleukin-2 (two patients). No patients in group A had local recurrence, whereas five out of the eight patients in group B did (<italic>p</italic> < 0.05, chi-square test). Median overall survival was 31 months in group A and 10 months in group B. Estimated overall survival using the Kaplan–Meier method was significantly longer in group A (<italic>p</italic> < 0.05, log-rank test). <italic>Conclusion: </italic>In our series, taxane-based chemotherapy was superior to conventional surgery-based therapy. Our results indicated that taxane regimens without mutilating surgery offered both local control and prevention of metastasis, which led to prolonged survival.</p> </abstract>