Association between gene polymorphisms of IL-28 and response to lamivudine in Chinese rural patients with chronic hepatitis B. (June 2013)

• Record Type: Journal Article
• Authors: Yu, Fengxue; Wang, Yanping; Yuan, Shang; Ma, Junji; Ma, Ning; Zhang, Xiaolin; Liu, Xuehui; Liu, Dianwu
• Is Part Of: Scandinavian journal of gastroenterology. Volume 48:Number 6(2013)
• Page Start: 745
• Page End: 751
• Publication Date: 2013-06
• Subjects: Gastroenterology -- Periodicals; Digestive organs -- Diseases -- Periodicals; 616.33
• DOI: 10.3109/00365521.2013.779746
• Languages: English
• ISSNs: 0036-5521

Abstract

<abstract> <title>Abstract</title> <p> <bold> <italic>Objective.</italic> </bold> To assess the association between gene polymorphisms (single nucleotide polymorphisms [SNPs]) of rs8099917 and rs12980602 in the IL-28 gene and the response to lamivudine treatment in naïve of Chinese rural patients. <bold><italic>Material and methods.</italic></bold> Three hundred and fifty-four naïve chronic hepatitis B (CHB) patients treated with lamivudine were enrolled in this study. Rs8099917 and rs12980602 SNPs were genotyped using matrix-assisted laser desorption/ionization time of flight mass spectrometry. Baseline characteristics and genotypes were compared between 181 patients with treatment response and 173 without response. <bold><italic>Results.</italic></bold> The IL-28 genotypes were independently associated with responses at 1 year post-treatment with lamivudine in CHB patients (OR for rs8099917 GT/GG vs. TT, 4.097 [95% CI, 1.342–12.512; <italic>p</italic> = 0.015]; OR for rs12980602CT/CC vs. TT, 2.27 [95% CI, 1.202–4.284; <italic>p</italic> =0.014]). When adjusting for age, gender, smoking, drinking, and levels of hepatitis B virus (HBV) DNA, alanine aminotransferase, and HBV genotype, the rs8099917 genotype GT (OR, 4.025 [95% CI, 1.316–12.354; <italic>p</italic> = 0.013] and fibrosis stage (OR, 0.716 [95% CI, 0.432–0.986; <italic>p</italic> = 0.036] appeared to be associated with a higher probability of response to lamivudine treatment. <bold><italic>Conclusion.</italic></bold> The genotype G/T for rs8099917 of IL-28 gene and early fibrosis stage may be predictive of treatment success.</p> </abstract>