Decreased sialylation of IgA1 O‐glycans associated with pneumococcal hemolytic uremic syndrome. Issue 6 (December 2013)

• Record Type: Journal Article
• Authors: Aoki, Hisaaki; Shiomi, Masashi; Ikeda, Tae; Ishii, Tsubura; Shimizu, Nobuhiko; Togawa, Masao; Okamoto, Nobuhiko; Kadoya, Machiko; Wada, Yoshinao
• Is Part Of: Pediatrics international. Volume 55:Issue 6(2013)
• Page Start: e143
• Page End: e145
• Publication Date: 2013-12
• Subjects: Pediatrics -- Periodicals; 618.92
• DOI: 10.1111/ped.12166
• Languages: English
• ISSNs: 1328-8067

Abstract

<abstract abstract-type="main"> <title>Abstract</title> <p>Hemolytic uremic syndrome (HUS) in children is usually caused by Shiga‐like toxin‐producing <italic>Escherichia coli</italic>, but approximately 5% of cases are caused by invasive pneumococcal infection (P‐HUS). Reported herein is the case of a 9‐month‐old HUS patient with pneumococcal meningitis who needed hemodialysis for 12 days. Decreased sialylation was characterized in both transferrin <italic>N</italic>‐glycans and IgA1 <italic>O</italic>‐glycans, analyzed in the acute phase on mass spectrometry, consistent with <italic>S. pneumonia</italic>‐produced sialidases hydrolyzing both α2, 3‐ and α2, 6‐linked sialic acids. The method will complement the T‐antigen activation test and help to understand the molecular pathology related to P‐HUS.</p> </abstract>