Micafungin versus fluconazole for prophylaxis against fungal infections in premature infants. Issue 6 (21st August 2013)

• Record Type: Journal Article
• Authors: Maede, Yoshinobu; Ibara, Satoshi; Nagasaki, Hiraku; Inoue, Takeshi; Tokuhisa, Takuya; Torikai, Motofumi; Ishihara, Chie; Matsui, Takako; Kodaira, Yuichi
• Is Part Of: Pediatrics international. Volume 55:Issue 6(2013)
• Page Start: 727
• Page End: 730
• Publication Date: 2013-08-21
• Subjects: Pediatrics -- Periodicals; 618.92
• DOI: 10.1111/ped.12157
• Languages: English
• ISSNs: 1328-8067

Abstract

<abstract abstract-type="main"> <title>Abstract</title> <sec id="ped12157-sec-0005" sec-type="section"> <title>Background</title> <p>We conducted a comparative clinical study to evaluate the prophylactic effects of micafungin (MCFG) and fluconazole (FLCZ) on the incidence of fungal infections in extremely low‐birthweight infants who were born at a gestational age of less than 26 weeks and weighed less than 1000 g.</p> </sec> <sec id="ped12157-sec-0006" sec-type="section"> <title>Methods</title> <p>With a combination of enteral administration of miconazole (6 mg/kg/day), FLCZ and MCFG were administered intravenously at a dose of 5 mg/kg/day and 3 mg/kg/day, respectively. The prophylaxis was classified as a failure when fungal infections were identified within the first 21 days after birth.</p> </sec> <sec id="ped12157-sec-0007" sec-type="section"> <title>Results</title> <p>The prophylaxis was successful in seven of 18 cases (39%) in the FLCZ group and 15 of 21 cases (71%) in the MCFG group, indicating that the success rate was significantly higher in the latter group.</p> </sec> <sec id="ped12157-sec-0008" sec-type="section"> <title>Conclusion</title> <p>MCFG was superior to FLCZ as prophylaxis against fungal infections in extremely low‐birthweight infants.</p> </sec> </abstract>