Adolescents and young adults with newly diagnosed Type 2 diabetes demonstrate greater carotid intima‐media thickness than those with Type 1 diabetes. Issue 1 (4th December 2013)

• Record Type: Journal Article
• Authors: Gu, W.; Huang, Y.; Zhang, Y.; Hong, J.; Liu, Y.; Zhan, W.; Ning, G.; Wang, W.
• Is Part Of: Diabetic medicine. Volume 31:Issue 1(2014:Jan.)
• Page Start: 84
• Page End: 91
• Publication Date: 2013-12-04
• Subjects: Diabetes -- Periodicals; 616.462
• DOI: 10.1111/dme.12335
• Languages: English
• ISSNs: 0742-3071

Abstract

<abstract abstract-type="main" id="dme12335-abs-0001"> <title>Abstract</title> <sec id="dme12335-sec-0001" sec-type="section"> <title>Aim</title> <p>To compare the carotid intima‐media thickness in patients with newly diagnosed Type 1 or Type 2 diabetes ranging from 14 to 30 years of age.</p> </sec> <sec id="dme12335-sec-0002" sec-type="section"> <title>Methods</title> <p>Demographic, anthropometric and laboratory data were obtained from 404 adolescents and young adults (103 subjects with Type 1 diabetes, 94 with Type 2 diabetes, 153 obese subjects and 54 normal control subjects). Carotid intima‐media thickness was assessed based on Doppler ultrasound examination and compared among the four groups.</p> </sec> <sec id="dme12335-sec-0003" sec-type="section"> <title>Results</title> <p>Our data showed significant increases in carotid intima‐media thickness in subjects with Type 1 diabetes, Type 2 diabetes and obese subjects compared with the control subjects, with those in the group with Type 2 diabetes demonstrating the greatest change (<italic>P</italic> < 0.001). Age, BMI, percentage of fat, waist–hip ratio and total triglycerides were significantly correlated with both common and internal carotid intima‐media thickness segments. From a stepwise multiple linear regression model, the independent determinants of common carotid intima‐media thickness were age, BMI, HbA<sub>1c</sub> and HDL cholesterol (adjusted <italic>R</italic><sup>2</sup> = 0.152, <italic>P</italic> < 0.001). After adjustment for age, sex and HbA<sub>1c</sub>, the odds ratio for increased carotid intima‐media thickness was 1.67 (95% CI 1.19–2.33, <italic>P</italic> = 0.003) for obese subjects, 2.38 (95% CI 1.59–9.47, <italic>P</italic> = 0.001) for subjects with Type 1 diabetes and 3.93 (95% CI 1.90–6.07, <italic>P</italic> = 0001) for subjects with Type 2 diabetes compared with the control subjects.</p> </sec> <sec id="dme12335-sec-0004" sec-type="section"> <title>Conclusions</title> <p>Compared with young control subjects, we found significant increases in carotid intima‐media thickness in patients with newly diagnosed Type 1 diabetes and Type 2 diabetes, with patients with Type 2 diabetes showing greater carotid intima‐media thickness. Traditional cardiovascular risk factors, such as obesity, dyslipidaemia, hypertension and hyperglycaemia, could cause vessel changes even in adolescents and young adults.</p> </sec> </abstract>