Commensals, probiotics and pathogens in the Caenorhabditis elegans model. (15th November 2013)

• Record Type: Journal Article
• Authors: Clark, Laura C.; Hodgkin, Jonathan
• Is Part Of: Cellular microbiology. Volume 16:Number 1(2014:Jan.)
• Page Start: 27
• Page End: 38
• Publication Date: 2013-11-15
• Subjects: Microbiology -- Periodicals; Cytology -- Periodicals; Host-parasite relationships -- Periodicals; Microbiology -- Periodicals; Cells -- Periodicals; Microbiologie -- Périodiques; Microbiologie; Relation hôte-parasite; Cytologie; Cellule; Réponse cellulaire; Ressource Internet (Descripteur de forme); Périodique électronique (Descripteur de forme); 579.05
• DOI: 10.1111/cmi.12234
• Languages: English
• ISSNs: 1462-5814

Abstract

<abstract abstract-type="main"> <title>Summary</title> <p> <italic>C</italic> <italic>aenorhabditis elegans</italic> is a useful model host for a wide variety of microorganisms that have implications for human health. Recent surveys of mammalian and metazoan microbiota demonstrate the often profound effects of gut commensal bacteria on host lifespan, health and development. Work using <italic>C</italic><italic>. elegans</italic> has revealed the surprising extent to which bacterial metabolism can interact with host pathways with examples from <italic>E</italic><italic>scherichia coli</italic> folate metabolism and <italic>B</italic><italic>acillus subtilis</italic> nitric oxide synthesis. The <italic>C</italic><italic>. elegans</italic> model has also shed light on the mechanisms by which probiotic bacteria influence lifespan.</p> </abstract>