Double‐positive CD4/CD8 mycosis fungoides: a rarely reported immunohistochemical profile. (20th November 2013)

• Record Type: Journal Article
• Authors: Tournier, Emilie; Laurent, Camille; Thomas, Marianne; Meyer, Nicolas; Viraben, Roland; Brousset, Pierre; Lamant, Laurence
• Is Part Of: Journal of cutaneous pathology. Volume 41:Number 1(2014:Jan.)
• Page Start: 58
• Page End: 62
• Publication Date: 2013-11-20
• Subjects: Skin -- Diseases -- Periodicals; Dermatology -- Periodicals; 616
• DOI: 10.1111/cup.12248
• Languages: English
• ISSNs: 0303-6987

Abstract

<abstract abstract-type="main" id="cup12248-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <p id="cup12248-para-0001">Mycosis fungoides (MF) represents the most common epidermotropic cutaneous T‐cell lymphoma (CTCL), and tumor cells typically express a mature T‐helper memory phenotype. A minority of MF patients display an unusual phenotype, which may be either CD4(−)/CD8(+) or double negative. Herein, we report a case of biopsy‐proven MF in a 31‐year‐old woman who presented with infiltrated plaques involving photoprotected areas of the skin. Immunohistochemical study combined with confocal microscopy revealed co‐expression of CD4 and CD8 in a subset of atypical T lymphocytes. To our knowledge, this is the second report of a CD4/CD8 dual‐positive MF.</p> </abstract>