Methylation of promoters of microRNAs and their host genes in myelodysplastic syndromes. Issue 12 (December 2013)

• Record Type: Journal Article
• Authors: Erdogan, Begum; Bosompem, Amma; Peng, Dunfa; Han, Leng; Smith, Emily; Kennedy, Mija E.; Alford, Catherine E.; Wu, Huiyun; Zhao, Zhongming; Mosse, Claudio A.; El-Rifai, Wael; Kim, Annette S.
• Is Part Of: Leukemia & lymphoma. Volume 54:Issue 12(2013:Dec.)
• Page Start: 2720
• Page End: 2727
• Publication Date: 2013-12
• Subjects: Leukemia -- Periodicals; Lymphomas -- Periodicals; 616.99419
• DOI: 10.3109/10428194.2013.790542
• Languages: English
• ISSNs: 1042-8194

Abstract

<abstract> <title>Abstract</title> <p>Myelodysplastic syndromes (MDS) are a group of hematopoietic malignancies characterized by ineffective hematopoiesis. Recently, we identified MDS-associated microRNAs (miRNAs) that are down-regulated in MDS. This study examines possible explanations for that observed down-regulation of miRNA expression in MDS. Since genomic losses are insufficient to explain the down-regulation of all our MDS-associated miRNAs, we explored other avenues. We demonstrate that these miRNAs are predominantly intragenic, and that, in many cases, they and their host genes are expressed in a similar pattern during myeloid maturation, suggesting their co-regulation. This co-regulation is further supported by the down-regulation of several of the host genes in MDS and increased methylation of the shared promoters of several miRNAs and their respective host genes. These studies identify a role of hypermethylation of miRNA promoters in the down-regulation of MDS-associated miRNAs, unifying research on miRNAs in MDS and epigenetic regulation in MDS into a common pathway.</p> </abstract>