Cyclophilin-A: a novel biomarker for untreated male essential hypertension. (December 2013)

• Record Type: Journal Article
• Authors: Chang, Chen-Shu; Su, Shih-Li; Chang, Chia-Chu; Lee, Kwo-Whei; Kuo, Chen-Ling; Huang, Ching-Shan; Tseng, Wan-Min; Liu, Chin-San
• Is Part Of: Biomarkers. Volume 18:Number 8(2013)
• Page Start: 716
• Page End: 720
• Publication Date: 2013-12
• Subjects: Biochemical markers -- Periodicals; 610.28
• DOI: 10.3109/1354750X.2013.847122
• Languages: English
• ISSNs: 1354-750X

Abstract

<abstract> <title>Abstract</title> <p>Vascular cytokines, total nitrite, and cyclophilin-A (CyP-A) may be related to the pathogenesis of untreated hypertension. Forty males with normotensive and untreated essential hypertension were recruited in this cytokines survey. Body mass index (BMI), hyperlipidemia, and plasma CyP-A were increased in the hypertensive group (<italic>p</italic> &lt; 0.05). However, only BMI (<italic>p</italic> = 0.022) and plasma CyP-A (<italic>p</italic> = 0.020) were found to be significant contributors to hypertension by multiple regression analysis. CyP-A was also positively correlated with systolic blood pressure (<italic>p</italic> = 0.029) and diastolic blood pressure (<italic>p</italic> = 0.047). These findings indicated that plasma CyP-A is a critical molecular biomarker in the early pathogenesis of essential hypertension.</p> </abstract>